Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis
Serotonin (5-HT3) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients. We conducted a systematic review on the comparative efficacy of 5-HT3 receptor antagonists. Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to...
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| Veröffentlicht in: | BMC medicine 2015-06, Vol.13 (1), p.136-136, Article 136 |
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| creator | Tricco, Andrea C Soobiah, Charlene Blondal, Erik Veroniki, Areti A Khan, Paul A Vafaei, Afshin Ivory, John Strifler, Lisa Ashoor, Huda MacDonald, Heather Reynen, Emily Robson, Reid Ho, Joanne Ng, Carmen Antony, Jesmin Mrklas, Kelly Hutton, Brian Hemmelgarn, Brenda R Moher, David Straus, Sharon E |
| description | Serotonin (5-HT3) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients. We conducted a systematic review on the comparative efficacy of 5-HT3 receptor antagonists.
Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT3 receptor antagonists with each other, placebo, and/or combined with other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.
Overall, 450 studies and 80,410 patients were included after the screening of 7,608 citations and 1,014 full-text articles. Significantly fewer patients experienced nausea with any drug relative to placebo, except for ondansetron plus metoclopramide in a NMA including 195 RCTs and 24,230 patients. Significantly fewer patients experienced vomiting with any drug relative to placebo except for palonosetron plus dexamethasone in NMA including 238 RCTs and 12,781 patients. All agents resulted in significantly fewer patients with postoperative nausea and vomiting versus placebo in a NMA including 125 RCTs and 16,667 patients.
Granisetron plus dexamethasone was often the most effective antiemetic, with the number needed to treat ranging from two to nine. |
| doi_str_mv | 10.1186/s12916-015-0371-y |
| format | Article |
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Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT3 receptor antagonists with each other, placebo, and/or combined with other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.
Overall, 450 studies and 80,410 patients were included after the screening of 7,608 citations and 1,014 full-text articles. Significantly fewer patients experienced nausea with any drug relative to placebo, except for ondansetron plus metoclopramide in a NMA including 195 RCTs and 24,230 patients. Significantly fewer patients experienced vomiting with any drug relative to placebo except for palonosetron plus dexamethasone in NMA including 238 RCTs and 12,781 patients. All agents resulted in significantly fewer patients with postoperative nausea and vomiting versus placebo in a NMA including 125 RCTs and 16,667 patients.
Granisetron plus dexamethasone was often the most effective antiemetic, with the number needed to treat ranging from two to nine.</description><identifier>ISSN: 1741-7015</identifier><identifier>EISSN: 1741-7015</identifier><identifier>DOI: 10.1186/s12916-015-0371-y</identifier><identifier>PMID: 26084277</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Antiemetics - therapeutic use ; Comparative analysis ; Humans ; Medical research ; Medicine, Experimental ; Methods ; Phenols ; Postoperative Nausea and Vomiting - prevention & control ; Registries ; Serotonin 5-HT3 Receptor Antagonists - therapeutic use ; Vomiting - prevention & control</subject><ispartof>BMC medicine, 2015-06, Vol.13 (1), p.136-136, Article 136</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Tricco et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-8a95faf7e912a8f95318dbbc6f24de72d2aa5b50d446caa93496e89841ed82713</citedby><cites>FETCH-LOGICAL-c633t-8a95faf7e912a8f95318dbbc6f24de72d2aa5b50d446caa93496e89841ed82713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472258/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4472258/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26084277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tricco, Andrea C</creatorcontrib><creatorcontrib>Soobiah, Charlene</creatorcontrib><creatorcontrib>Blondal, Erik</creatorcontrib><creatorcontrib>Veroniki, Areti A</creatorcontrib><creatorcontrib>Khan, Paul A</creatorcontrib><creatorcontrib>Vafaei, Afshin</creatorcontrib><creatorcontrib>Ivory, John</creatorcontrib><creatorcontrib>Strifler, Lisa</creatorcontrib><creatorcontrib>Ashoor, Huda</creatorcontrib><creatorcontrib>MacDonald, Heather</creatorcontrib><creatorcontrib>Reynen, Emily</creatorcontrib><creatorcontrib>Robson, Reid</creatorcontrib><creatorcontrib>Ho, Joanne</creatorcontrib><creatorcontrib>Ng, Carmen</creatorcontrib><creatorcontrib>Antony, Jesmin</creatorcontrib><creatorcontrib>Mrklas, Kelly</creatorcontrib><creatorcontrib>Hutton, Brian</creatorcontrib><creatorcontrib>Hemmelgarn, Brenda R</creatorcontrib><creatorcontrib>Moher, David</creatorcontrib><creatorcontrib>Straus, Sharon E</creatorcontrib><title>Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis</title><title>BMC medicine</title><addtitle>BMC Med</addtitle><description>Serotonin (5-HT3) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients. We conducted a systematic review on the comparative efficacy of 5-HT3 receptor antagonists.
Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT3 receptor antagonists with each other, placebo, and/or combined with other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.
Overall, 450 studies and 80,410 patients were included after the screening of 7,608 citations and 1,014 full-text articles. Significantly fewer patients experienced nausea with any drug relative to placebo, except for ondansetron plus metoclopramide in a NMA including 195 RCTs and 24,230 patients. Significantly fewer patients experienced vomiting with any drug relative to placebo except for palonosetron plus dexamethasone in NMA including 238 RCTs and 12,781 patients. All agents resulted in significantly fewer patients with postoperative nausea and vomiting versus placebo in a NMA including 125 RCTs and 16,667 patients.
Granisetron plus dexamethasone was often the most effective antiemetic, with the number needed to treat ranging from two to nine.</description><subject>Antiemetics - therapeutic use</subject><subject>Comparative analysis</subject><subject>Humans</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Methods</subject><subject>Phenols</subject><subject>Postoperative Nausea and Vomiting - prevention & control</subject><subject>Registries</subject><subject>Serotonin 5-HT3 Receptor Antagonists - therapeutic use</subject><subject>Vomiting - prevention & control</subject><issn>1741-7015</issn><issn>1741-7015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptktGK1DAUhoso7rr6AN5IQJD1omuTJk3rhbAM6goL3qzX4Ux60om2yZiks_QdfGgzzLrMgOQih3O-_-ck_EXxmlZXlLbNh0hZR5uyoqKsaknL5UlxTiWnpcytp0f1WfEixp9VxYSU_Hlxxpqq5UzK8-LPyk9bCJDsDgkaYzXohXhDIgafvLOOXIry5q5-TwJq3CYfCLgEQx7FFEmeb7MYXa5n12MYvHUDiXMYMCwfCZC4xIRTZnR22Fm8z_qeOEz3PvwiEyYowcG4RBtfFs8MjBFfPdwXxY8vn-9WN-Xt96_fVte3pW7qOpUtdMKAkdhRBq3pRE3bfr3WjWG8R8l6BiDWouo5bzRAV_OuwbZrOcW-ZZLWF8Wng-92Xk_Y67x9gFFtg50gLMqDVacTZzdq8DvFuWRMtNng8sEg-N8zxqQmGzWOIzj0c1S06SpGZcPqjL49oAOMqKwzPjvqPa6uBac8L1-LTF39h8qnx8lq79DY3D8RvDsSbBDGtIl-nJP1Lp6C9ADq4GMMaB6fSSu1T5E6pEjlmKh9itSSNW-O_-dR8S829V8W3sTw</recordid><startdate>20150618</startdate><enddate>20150618</enddate><creator>Tricco, Andrea C</creator><creator>Soobiah, Charlene</creator><creator>Blondal, Erik</creator><creator>Veroniki, Areti A</creator><creator>Khan, Paul A</creator><creator>Vafaei, Afshin</creator><creator>Ivory, John</creator><creator>Strifler, Lisa</creator><creator>Ashoor, Huda</creator><creator>MacDonald, Heather</creator><creator>Reynen, Emily</creator><creator>Robson, Reid</creator><creator>Ho, Joanne</creator><creator>Ng, Carmen</creator><creator>Antony, Jesmin</creator><creator>Mrklas, Kelly</creator><creator>Hutton, Brian</creator><creator>Hemmelgarn, Brenda R</creator><creator>Moher, David</creator><creator>Straus, Sharon E</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150618</creationdate><title>Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis</title><author>Tricco, Andrea C ; 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We conducted a systematic review on the comparative efficacy of 5-HT3 receptor antagonists.
Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT3 receptor antagonists with each other, placebo, and/or combined with other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.
Overall, 450 studies and 80,410 patients were included after the screening of 7,608 citations and 1,014 full-text articles. Significantly fewer patients experienced nausea with any drug relative to placebo, except for ondansetron plus metoclopramide in a NMA including 195 RCTs and 24,230 patients. Significantly fewer patients experienced vomiting with any drug relative to placebo except for palonosetron plus dexamethasone in NMA including 238 RCTs and 12,781 patients. All agents resulted in significantly fewer patients with postoperative nausea and vomiting versus placebo in a NMA including 125 RCTs and 16,667 patients.
Granisetron plus dexamethasone was often the most effective antiemetic, with the number needed to treat ranging from two to nine.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26084277</pmid><doi>10.1186/s12916-015-0371-y</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC medicine, 2015-06, Vol.13 (1), p.136-136, Article 136 |
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| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Antiemetics - therapeutic use Comparative analysis Humans Medical research Medicine, Experimental Methods Phenols Postoperative Nausea and Vomiting - prevention & control Registries Serotonin 5-HT3 Receptor Antagonists - therapeutic use Vomiting - prevention & control |
| title | Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis |
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