Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury

Deep second-degree burns are characterized by delayed formation of granulation tissue and impaired angiogenesis. Erythropoietin (EPO) is able to stimulate angiogenesis and mitosis, activating vascularization and cell cycle. The aim of our study was to investigate whether two biosimilar recombinant h...

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Veröffentlicht in:	BioMed research international 2015-01, Vol.2015 (2015), p.1-9
Hauptverfasser:	Minutoli, Letteria, Colonna, Michele Rosario, Altavilla, Domenica, Stagno d’Alcontres, Ferdinando, Stagno d’Alcontres, Francesco, Galeano, Mariarosaria, Squadrito, Francesco, Vaccaro, Mario, Pizzino, Gabriele, Bitto, Alessandra, Irrera, Natasha, Buemi, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Brain Injuries - drug therapy Brain Injuries - genetics Burns Burns - drug therapy Burns - physiopathology Burns and scalds Care and treatment Cell cycle Comparative analysis Epoetin Alfa - administration & dosage Epoetin Alfa - genetics Erythropoietin Erythropoietin - administration & dosage Erythropoietin - genetics Gene Expression Regulation - drug effects Health aspects Humans Laboratory animals Mice Models, Theoretical Neovascularization Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - genetics Physiology Recombinant Proteins - administration & dosage Recombinant Proteins - genetics Regulatory approval Studies Vascular endothelial growth factor Vascular Endothelial Growth Factor A - biosynthesis Vascular Endothelial Growth Factor A - genetics Wound healing Wound Healing - drug effects Wound Healing - genetics Wounds and injuries
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