Neurocognitive dysfunction and pharmacological intervention using guanfacine in a rhesus macaque model of self-injurious behavior

Self-injurious behavior (SIB) is a common comorbidity of psychiatric disorders but there is a dearth of information about neurological mechanisms underlying the behavior, and few animal models exist. SIB in humans is characterized by any intentional self-directed behavior that leads to wounds, where...

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Veröffentlicht in:	Translational psychiatry 2015-05, Vol.5 (5), p.e567-e567
Hauptverfasser:	Freeman, Z T, Rice, K A, Soto, P L, Pate, K A M, Weed, M R, Ator, N A, DeLeon, I G, Wong, D F, Zhou, Y, Mankowski, J L, Zink, M C, Adams, R J, Hutchinson, E K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378 64 692/699/476 Adrenergic alpha-2 Receptor Agonists - pharmacology Adrenergic alpha-2 Receptor Agonists - therapeutic use Animals Attention - physiology Behavior, Animal - drug effects Behavioral Sciences Biological Psychology Carbon Radioisotopes Cognition - physiology Cognition Disorders - physiopathology Disease Models, Animal Dopamine Antagonists Guanfacine - pharmacology Guanfacine - therapeutic use Impulsive Behavior - drug effects Impulsive Behavior - physiology Macaca mulatta Male Medicine Medicine & Public Health Neostriatum - diagnostic imaging Neostriatum - metabolism Neostriatum - physiopathology Neuropsychological Tests Neurosciences Original original-article Pharmacotherapy Positron-Emission Tomography Psychiatry Raclopride Random Allocation Reaction Time Receptors, Dopamine - metabolism Self-Injurious Behavior - drug therapy Self-Injurious Behavior - physiopathology Severity of Illness Index
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