Developmental changes in structural and functional properties of hippocampal AMPARs parallels the emergence of deliberative spatial navigation in juvenile rats

The neural mechanisms that support the late postnatal development of spatial navigation are currently unknown. We investigated this in rats and found that an increase in the duration of AMPAR-mediated synaptic responses in the hippocampus was related to the emergence of spatial navigation. More spec...

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Veröffentlicht in:	The Journal of neuroscience 2013-07, Vol.33 (30), p.12218-12228
Hauptverfasser:	Blair, Margaret G, Nguyen, Nhu N-Q, Albani, Sarah H, L'Etoile, Matthew M, Andrawis, Marina M, Owen, Leanna M, Oliveira, Rodrigo F, Johnson, Matthew W, Purvis, Dianna L, Sanders, Erin M, Stoneham, Emily T, Xu, Huaying, Dumas, Theodore C
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals CA1 Region, Hippocampal - growth & development CA1 Region, Hippocampal - physiology Calcium Channels - physiology Electrophysiology Evoked Potentials - physiology Excitatory Postsynaptic Potentials - physiology Female Male Maze Learning - physiology Neuronal Plasticity - physiology Organ Culture Techniques Oxazines - pharmacology Rats Rats, Long-Evans Receptors, AMPA - agonists Receptors, AMPA - physiology Space Perception - physiology Synapses - physiology
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