Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model
HIV-associated mortality has been significantly reduced with antiretroviral therapy (ART), and HIV infection has become a chronic disease that frequently coexists with many disorders, including substance abuse (Azar et al. Drug Alcohol Depend 112:178–193, 2010 ; Phillips et al. J Gen Int Med 16:165,...
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| Veröffentlicht in: | Journal of neuroimmune pharmacology 2015-06, Vol.10 (2), p.217-232 |
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| creator | Molina, Patricia E. Amedee, Angela M. Winsauer, Peter Nelson, Steve Bagby, Gregory Simon, Liz |
| description | HIV-associated mortality has been significantly reduced with antiretroviral therapy (ART), and HIV infection has become a chronic disease that frequently coexists with many disorders, including substance abuse (Azar et al. Drug Alcohol Depend 112:178–193,
2010
; Phillips et al. J Gen Int Med 16:165,
2001
). Alcohol and drugs of abuse may modify host-pathogen interactions at various levels including behavioral, metabolic, and immune consequences of HIV infection, as well as the ability of the virus to integrate into the genome and replicate in host cells. Identifying mechanisms responsible for these interactions is complicated by many factors, such as the tissue specific responses to viral infection, multiple cellular mechanisms involved in inflammatory responses, neuroendocrine and localized responses to infection, and kinetics of viral replication. An integrated physiological analysis of the biomedical consequences of chronic alcohol and drug use or abuse on disease progression is possible using rhesus macaques infected with simian immunodeficiency virus (SIV), a relevant model of HIV infection. This review will provide an overview of the data gathered using this model to show that chronic administration of two of the most commonly abused substances, alcohol and cannabinoids (Δ
9
-Tetrahydrocannabinol; THC), affect host-pathogen interactions. |
| doi_str_mv | 10.1007/s11481-015-9599-8 |
| format | Article |
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2010
; Phillips et al. J Gen Int Med 16:165,
2001
). Alcohol and drugs of abuse may modify host-pathogen interactions at various levels including behavioral, metabolic, and immune consequences of HIV infection, as well as the ability of the virus to integrate into the genome and replicate in host cells. Identifying mechanisms responsible for these interactions is complicated by many factors, such as the tissue specific responses to viral infection, multiple cellular mechanisms involved in inflammatory responses, neuroendocrine and localized responses to infection, and kinetics of viral replication. An integrated physiological analysis of the biomedical consequences of chronic alcohol and drug use or abuse on disease progression is possible using rhesus macaques infected with simian immunodeficiency virus (SIV), a relevant model of HIV infection. This review will provide an overview of the data gathered using this model to show that chronic administration of two of the most commonly abused substances, alcohol and cannabinoids (Δ
9
-Tetrahydrocannabinol; THC), affect host-pathogen interactions.</description><identifier>ISSN: 1557-1890</identifier><identifier>EISSN: 1557-1904</identifier><identifier>DOI: 10.1007/s11481-015-9599-8</identifier><identifier>PMID: 25795088</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Alcohol ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cannabinoids - administration & dosage ; Cannabinoids - toxicity ; Cell Biology ; Chronic illnesses ; Disease Progression ; Ethanol - administration & dosage ; Ethanol - toxicity ; HIV ; HIV Infections - etiology ; HIV Infections - immunology ; Human immunodeficiency virus ; Humans ; Immunology ; Infections ; Invited Review ; Macaca mulatta ; Metabolism ; Neurosciences ; Pharmacology/Toxicology ; Simian Acquired Immunodeficiency Syndrome - etiology ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Immunodeficiency Virus ; Viral infections ; Virology</subject><ispartof>Journal of neuroimmune pharmacology, 2015-06, Vol.10 (2), p.217-232</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>Journal of Neuroimmune Pharmacology is a copyright of Springer, 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-7689cbb1b343de5a694b78b740f74e105972a4ce1454722e4e28ce254a60ff5a3</citedby><cites>FETCH-LOGICAL-c540t-7689cbb1b343de5a694b78b740f74e105972a4ce1454722e4e28ce254a60ff5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11481-015-9599-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11481-015-9599-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25795088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Molina, Patricia E.</creatorcontrib><creatorcontrib>Amedee, Angela M.</creatorcontrib><creatorcontrib>Winsauer, Peter</creatorcontrib><creatorcontrib>Nelson, Steve</creatorcontrib><creatorcontrib>Bagby, Gregory</creatorcontrib><creatorcontrib>Simon, Liz</creatorcontrib><title>Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model</title><title>Journal of neuroimmune pharmacology</title><addtitle>J Neuroimmune Pharmacol</addtitle><addtitle>J Neuroimmune Pharmacol</addtitle><description>HIV-associated mortality has been significantly reduced with antiretroviral therapy (ART), and HIV infection has become a chronic disease that frequently coexists with many disorders, including substance abuse (Azar et al. Drug Alcohol Depend 112:178–193,
2010
; Phillips et al. J Gen Int Med 16:165,
2001
). Alcohol and drugs of abuse may modify host-pathogen interactions at various levels including behavioral, metabolic, and immune consequences of HIV infection, as well as the ability of the virus to integrate into the genome and replicate in host cells. Identifying mechanisms responsible for these interactions is complicated by many factors, such as the tissue specific responses to viral infection, multiple cellular mechanisms involved in inflammatory responses, neuroendocrine and localized responses to infection, and kinetics of viral replication. An integrated physiological analysis of the biomedical consequences of chronic alcohol and drug use or abuse on disease progression is possible using rhesus macaques infected with simian immunodeficiency virus (SIV), a relevant model of HIV infection. This review will provide an overview of the data gathered using this model to show that chronic administration of two of the most commonly abused substances, alcohol and cannabinoids (Δ
9
-Tetrahydrocannabinol; THC), affect host-pathogen interactions.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Alcohol</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cannabinoids - administration & dosage</subject><subject>Cannabinoids - toxicity</subject><subject>Cell Biology</subject><subject>Chronic illnesses</subject><subject>Disease Progression</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - toxicity</subject><subject>HIV</subject><subject>HIV Infections - etiology</subject><subject>HIV Infections - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infections</subject><subject>Invited Review</subject><subject>Macaca mulatta</subject><subject>Metabolism</subject><subject>Neurosciences</subject><subject>Pharmacology/Toxicology</subject><subject>Simian Acquired Immunodeficiency Syndrome - etiology</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Immunodeficiency Virus</subject><subject>Viral infections</subject><subject>Virology</subject><issn>1557-1890</issn><issn>1557-1904</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1UU1v1DAQjRCIlsIP4IIscW2onR2vbQ5IS_jYSC0gFXq1HGfSuErs1k4q8RP413i1bVUOnGakee_Nm3lF8ZrRd4xScZIYA8lKynipuFKlfFIcMs5FyRSFp_e9VPSgeJHSFaUAQOnz4qDiQnEq5WHx5yMO5taFaMZjcoazacPo7DExviPNNC0eSR18wpsFvcVEQk_qIQbvLNmMNgxhJCGS2nhvWueD6zLEk21zcbJpPqX35HxeOpd5zpN5QPIt-HK7TMaTH9FNZkZy3lyQs9Dh-LJ41psx4au7elT8-vL5Z70tT79_berNaWk50LkUa6ls27J2BasOuVkraIVsBdBeADLKlagMWGTAQVQVAlbSYsXBrGnfc7M6Kj7sda-XdsLOop_z8fp65yf-1sE4_e_Eu0FfhlsNIKioVlng7Z1ADPktadZXYYk-e9Ysf1UwAEYziu1RNoaUIvYPGxjVu_T0Pj2d09O79LTMnDePrT0w7uPKgGoPSHnkLzE-Wv1f1b9GiqVi</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Molina, Patricia E.</creator><creator>Amedee, Angela M.</creator><creator>Winsauer, Peter</creator><creator>Nelson, Steve</creator><creator>Bagby, Gregory</creator><creator>Simon, Liz</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model</title><author>Molina, Patricia E. ; Amedee, Angela M. ; Winsauer, Peter ; Nelson, Steve ; Bagby, Gregory ; Simon, Liz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-7689cbb1b343de5a694b78b740f74e105972a4ce1454722e4e28ce254a60ff5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Alcohol</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cannabinoids - administration & dosage</topic><topic>Cannabinoids - toxicity</topic><topic>Cell Biology</topic><topic>Chronic illnesses</topic><topic>Disease Progression</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - toxicity</topic><topic>HIV</topic><topic>HIV Infections - etiology</topic><topic>HIV Infections - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infections</topic><topic>Invited Review</topic><topic>Macaca mulatta</topic><topic>Metabolism</topic><topic>Neurosciences</topic><topic>Pharmacology/Toxicology</topic><topic>Simian Acquired Immunodeficiency Syndrome - etiology</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Immunodeficiency Virus</topic><topic>Viral infections</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Molina, Patricia E.</creatorcontrib><creatorcontrib>Amedee, Angela M.</creatorcontrib><creatorcontrib>Winsauer, Peter</creatorcontrib><creatorcontrib>Nelson, Steve</creatorcontrib><creatorcontrib>Bagby, Gregory</creatorcontrib><creatorcontrib>Simon, Liz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimmune pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Molina, Patricia E.</au><au>Amedee, Angela M.</au><au>Winsauer, Peter</au><au>Nelson, Steve</au><au>Bagby, Gregory</au><au>Simon, Liz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model</atitle><jtitle>Journal of neuroimmune pharmacology</jtitle><stitle>J Neuroimmune Pharmacol</stitle><addtitle>J Neuroimmune Pharmacol</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>10</volume><issue>2</issue><spage>217</spage><epage>232</epage><pages>217-232</pages><issn>1557-1890</issn><eissn>1557-1904</eissn><abstract>HIV-associated mortality has been significantly reduced with antiretroviral therapy (ART), and HIV infection has become a chronic disease that frequently coexists with many disorders, including substance abuse (Azar et al. Drug Alcohol Depend 112:178–193,
2010
; Phillips et al. J Gen Int Med 16:165,
2001
). Alcohol and drugs of abuse may modify host-pathogen interactions at various levels including behavioral, metabolic, and immune consequences of HIV infection, as well as the ability of the virus to integrate into the genome and replicate in host cells. Identifying mechanisms responsible for these interactions is complicated by many factors, such as the tissue specific responses to viral infection, multiple cellular mechanisms involved in inflammatory responses, neuroendocrine and localized responses to infection, and kinetics of viral replication. An integrated physiological analysis of the biomedical consequences of chronic alcohol and drug use or abuse on disease progression is possible using rhesus macaques infected with simian immunodeficiency virus (SIV), a relevant model of HIV infection. This review will provide an overview of the data gathered using this model to show that chronic administration of two of the most commonly abused substances, alcohol and cannabinoids (Δ
9
-Tetrahydrocannabinol; THC), affect host-pathogen interactions.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25795088</pmid><doi>10.1007/s11481-015-9599-8</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of neuroimmune pharmacology, 2015-06, Vol.10 (2), p.217-232 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acquired immune deficiency syndrome AIDS Alcohol Animals Biomedical and Life Sciences Biomedicine Cannabinoids - administration & dosage Cannabinoids - toxicity Cell Biology Chronic illnesses Disease Progression Ethanol - administration & dosage Ethanol - toxicity HIV HIV Infections - etiology HIV Infections - immunology Human immunodeficiency virus Humans Immunology Infections Invited Review Macaca mulatta Metabolism Neurosciences Pharmacology/Toxicology Simian Acquired Immunodeficiency Syndrome - etiology Simian Acquired Immunodeficiency Syndrome - immunology Simian Immunodeficiency Virus Viral infections Virology |
| title | Behavioral, Metabolic, and Immune Consequences of Chronic Alcohol or Cannabinoids on HIV/AIDs: Studies in the Non-Human Primate SIV Model |
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