Low-pathogenicity mycoplasma species induce immunoparesis and are highly prevalent amongst patients with ventilator-associated pneumonia

Low-pathogenicity mycoplasma species induce immunoparesis and are highly prevalent amongst patients with ventilator-associated pneumonia

Methods Two cohorts [1, 2], totalling 159 patients, were recruited from 12 UK ICUs; all patients had suspected VAP and underwent bronchoscopy and bronchoalveolar lavage. Human blood monocytes and MDM incubated with M. salivarium displayed impaired cytokine responses to lipopolysaccharide and MDM dem...

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Veröffentlicht in:Critical care (London, England) England), 2015-03, Vol.19 (S1), p.P89-P89, Article P89
Hauptverfasser: Nolan, TJ, Gadsby, N, Hellyer, TP, Templeton, K, McMullan, R, McKenna, J, Rennie, J, Robb, CT, Walsh, TS, Rossi, AG, Simpson, AJ, Morris, A Conway
Format: Artikel
Sprache:eng
Schlagworte:
Causes of
Evaluation
Host-bacteria relationships
Identification and classification
Mycoplasma
Pathogenesis
Pneumonia
Poster Presentation
Prevalence studies (Epidemiology)
Ventilator-associated pneumonia
Ventilators
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Zusammenfassung:Methods Two cohorts [1, 2], totalling 159 patients, were recruited from 12 UK ICUs; all patients had suspected VAP and underwent bronchoscopy and bronchoalveolar lavage. Human blood monocytes and MDM incubated with M. salivarium displayed impaired cytokine responses to lipopolysaccharide and MDM demonstrated impaired phagocytosis.
ISSN:1364-8535
1364-8535
1366-609X
1466-609X
DOI:10.1186/cc14169