ANKS1B Gene Product AIDA-1 Controls Hippocampal Synaptic Transmission by Regulating GluN2B Subunit Localization

NMDA receptors (NMDARs) are key mediators of glutamatergic transmission and synaptic plasticity, and their dysregulation has been linked to diverse neuropsychiatric and neurodegenerative disorders. While normal NMDAR function requires regulated expression and trafficking of its different subunits, t...

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Veröffentlicht in:	The Journal of neuroscience 2015-06, Vol.35 (24), p.8986-8996
Hauptverfasser:	Tindi, Jaafar O, Chávez, Andrés E, Cvejic, Svetlana, Calvo-Ochoa, Erika, Castillo, Pablo E, Jordan, Bryen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - physiology Cells, Cultured Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - physiology Female Hippocampus - chemistry Hippocampus - physiology Male Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Protein Subunits - analysis Protein Subunits - physiology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - analysis Receptors, N-Methyl-D-Aspartate - physiology Synapses - chemistry Synapses - physiology Synaptic Transmission - physiology
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