Type 1 diabetes and gut microbiota: Friend or foe?
Type 1 diabetes is a T cell-mediated autoimmune disease. Environmental factors play an important role in the initiation of the disease in genetically predisposed individuals. With the improved control of infectious disease, the incidence of autoimmune diseases, particularly type 1 diabetes, has dram...
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| Veröffentlicht in: | Pharmacological research 2015-08, Vol.98, p.9-15 |
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| creator | Hu, Changyun Wong, F. Susan Wen, Li |
| description | Type 1 diabetes is a T cell-mediated autoimmune disease. Environmental factors play an important role in the initiation of the disease in genetically predisposed individuals. With the improved control of infectious disease, the incidence of autoimmune diseases, particularly type 1 diabetes, has dramatically increased in developed countries. Increasing evidence suggests that gut microbiota are involved in the pathogenesis of type 1 diabetes. Here we focus on recent advances in this field and provide a rationale for novel therapeutic strategies targeting gut microbiota for the prevention of type 1 diabetes. |
| doi_str_mv | 10.1016/j.phrs.2015.02.006 |
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Here we focus on recent advances in this field and provide a rationale for novel therapeutic strategies targeting gut microbiota for the prevention of type 1 diabetes.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2015.02.006</identifier><identifier>PMID: 25747961</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Autoimmunity ; Diabetes Mellitus, Type 1 - microbiology ; Diabetes Mellitus, Type 1 - therapy ; Gastrointestinal Microbiome - physiology ; Gastrointestinal Tract - immunology ; Gastrointestinal Tract - microbiology ; Gut microbiota ; Humans ; Mice, Inbred NOD ; NOD mice ; Type 1 diabetes</subject><ispartof>Pharmacological research, 2015-08, Vol.98, p.9-15</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. 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Here we focus on recent advances in this field and provide a rationale for novel therapeutic strategies targeting gut microbiota for the prevention of type 1 diabetes.</description><subject>Animals</subject><subject>Autoimmunity</subject><subject>Diabetes Mellitus, Type 1 - microbiology</subject><subject>Diabetes Mellitus, Type 1 - therapy</subject><subject>Gastrointestinal Microbiome - physiology</subject><subject>Gastrointestinal Tract - immunology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Gut microbiota</subject><subject>Humans</subject><subject>Mice, Inbred NOD</subject><subject>NOD mice</subject><subject>Type 1 diabetes</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMofv8BD7JHL7tOsvnYiCgifoHgpZ5DNjtbU9qmJtuC_96UqujF0wwz77wz8xByQqGiQOX5pFq8xVQxoKICVgHILbJPQcuS0kZur3Nel1LSZo8cpDQBAM0p7JI9JhRXWtJ9wkYfCyxo0Xnb4oCpsPOuGC-HYuZdDK0Pg70o7qPHXA6x6ANeH5Gd3k4THn_FQ_J6fze6fSyfXx6ebm-eSyeYGEppO-4aVD23mqNrNSglVNcIIXtBKTaaC9E0wIF3WtRtzXulRcNZr5ApwPqQXG18F8t2hp3D-RDt1Cyin9n4YYL15m9n7t_MOKwM51ILENng7MsghvclpsHMfHI4ndo5hmUyVEGtqNBSZynbSPPTKUXsf9ZQMGvYZmLWsM0atgFmMuw8dPr7wJ-Rb7pZcLkRYMa08hhNcpmkw85HdIPpgv_P_xNRX47h</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Hu, Changyun</creator><creator>Wong, F. 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| ispartof | Pharmacological research, 2015-08, Vol.98, p.9-15 |
| issn | 1043-6618 1096-1186 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autoimmunity Diabetes Mellitus, Type 1 - microbiology Diabetes Mellitus, Type 1 - therapy Gastrointestinal Microbiome - physiology Gastrointestinal Tract - immunology Gastrointestinal Tract - microbiology Gut microbiota Humans Mice, Inbred NOD NOD mice Type 1 diabetes |
| title | Type 1 diabetes and gut microbiota: Friend or foe? |
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