Interspecies Pharmacokinetic Modeling of Subcutaneous Absorption of Rituximab in Mice and Rats

Purpose To investigate the effect of dose level and anatomical site of injection on the pharmacokinetics of rituximab in mice, and to evaluate the utility of a pharmacokinetic model for describing interspecies differences in subcutaneous absorption between mice and rats. Methods Rituximab serum conc...

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Veröffentlicht in:	Pharmaceutical research 2014-12, Vol.31 (12), p.3265-3273
Hauptverfasser:	Kagan, Leonid, Zhao, Jie, Mager, Donald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Murine-Derived - administration & dosage Antibodies, Monoclonal, Murine-Derived - pharmacokinetics Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Bioavailability Biochemistry Biological Availability Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Body Weight Dose-Response Relationship, Drug Injections, Intravenous Injections, Subcutaneous Male Mathematical models Medical Law Mice Mice, Inbred C57BL Models, Statistical Pharmacology Pharmacology/Toxicology Pharmacy Rats Research Paper Rituximab Rodents Skin Absorption Species Specificity Subcutaneous Absorption
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