Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway

Breast cancer progression is promoted by stromal cells that populate the tumors, including cancer-associated fibroblasts (CAFs) and mesenchymal stem/stromal cells (MSCs). The activities of CAFs and MSCs in breast cancer are integrated within an intimate inflammatory tumor microenvironment (TME) that...

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Veröffentlicht in:	Stem cell research & therapy 2015-05, Vol.6 (1), p.87-87, Article 87
Hauptverfasser:	Katanov, Christina, Lerrer, Shalom, Liubomirski, Yulia, Leider-Trejo, Leonor, Meshel, Tsipi, Bar, Jair, Feniger-Barish, Rotem, Kamer, Iris, Soria-Artzi, Gali, Kahani, Hadar, Banerjee, Debabrata, Ben-Baruch, Adit
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Bone Marrow Cells - cytology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Chemokine CCL2 - analysis Chemokine CCL5 - analysis Culture Media, Conditioned - pharmacology Female Fibroblasts - cytology Fibroblasts - metabolism Humans Interleukin-1beta - pharmacology Interleukin-8 - analysis JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism MCF-7 Cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism NF-kappa B - metabolism RNA Interference Signal Transduction Transcription Factor RelA - antagonists & inhibitors Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Up-Regulation - drug effects
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