Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection
This randomized, controlled trial involving patients with complicated intraabdominal infections and proper source control showed similar outcomes after fixed-duration antimicrobial therapy (4 days) and after a longer course (approximately 8 days). Complicated intraabdominal infection continues to be...
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| Veröffentlicht in: | The New England journal of medicine 2015-05, Vol.372 (21), p.1996-2005 |
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| container_end_page | 2005 |
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| container_issue | 21 |
| container_start_page | 1996 |
| container_title | The New England journal of medicine |
| container_volume | 372 |
| creator | Sawyer, Robert G Claridge, Jeffrey A Nathens, Avery B Rotstein, Ori D Duane, Therese M Evans, Heather L Cook, Charles H O’Neill, Patrick J Mazuski, John E Askari, Reza Wilson, Mark A Napolitano, Lena M Namias, Nicholas Miller, Preston R Dellinger, E. Patchen Watson, Christopher M Coimbra, Raul Dent, Daniel L Lowry, Stephen F Cocanour, Christine S West, Michaela A Banton, Kaysie L Cheadle, William G Lipsett, Pamela A Guidry, Christopher A Popovsky, Kimberley |
| description | This randomized, controlled trial involving patients with complicated intraabdominal infections and proper source control showed similar outcomes after fixed-duration antimicrobial therapy (4 days) and after a longer course (approximately 8 days).
Complicated intraabdominal infection continues to be a common problem worldwide. Approximately 300,000 cases of appendicitis occur each year in the United States,
1
and at least twice that many cases of non-appendiceal infection require management.
2
Morbidity ranges from 5% among patients evaluated in broad observational studies
2
–
4
to close to 50% in some cohorts, such as the elderly or critically ill.
5
,
6
Despite the diversity of specific processes in these infections, the basic tenets of management are similar: resuscitate patients who have the systemic inflammatory response syndrome (SIRS), control the source of contamination, remove most of the infected or necrotic material, . . . |
| doi_str_mv | 10.1056/NEJMoa1411162 |
| format | Article |
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Complicated intraabdominal infection continues to be a common problem worldwide. Approximately 300,000 cases of appendicitis occur each year in the United States,
1
and at least twice that many cases of non-appendiceal infection require management.
2
Morbidity ranges from 5% among patients evaluated in broad observational studies
2
–
4
to close to 50% in some cohorts, such as the elderly or critically ill.
5
,
6
Despite the diversity of specific processes in these infections, the basic tenets of management are similar: resuscitate patients who have the systemic inflammatory response syndrome (SIRS), control the source of contamination, remove most of the infected or necrotic material, . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1411162</identifier><identifier>PMID: 25992746</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - administration & dosage ; Antibiotics ; Antimicrobial agents ; Appendicitis ; Appendicitis - drug therapy ; Drug Administration Schedule ; Drug therapy ; Female ; Fever ; Fever - etiology ; Humans ; Infections ; Intraabdominal Infections - complications ; Intraabdominal Infections - drug therapy ; Intraabdominal Infections - mortality ; Kaplan-Meier Estimate ; Leukocytosis ; Leukocytosis - etiology ; Male ; Medical research ; Medication Adherence ; Middle Aged ; Patients ; Peritonitis - etiology ; Recurrence ; Recurrent infection ; Sepsis - drug therapy ; Surgical site infections ; Surgical Wound Infection - etiology ; Young Adult</subject><ispartof>The New England journal of medicine, 2015-05, Vol.372 (21), p.1996-2005</ispartof><rights>Copyright © 2015 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2015 Massachusetts Medical Society. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-97cccfbccbb159ed4338b2585af0bd965c7e9e65d0d954d1ac239fb96e8205e33</citedby><cites>FETCH-LOGICAL-c511t-97cccfbccbb159ed4338b2585af0bd965c7e9e65d0d954d1ac239fb96e8205e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1411162$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1411162$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25992746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sawyer, Robert G</creatorcontrib><creatorcontrib>Claridge, Jeffrey A</creatorcontrib><creatorcontrib>Nathens, Avery B</creatorcontrib><creatorcontrib>Rotstein, Ori D</creatorcontrib><creatorcontrib>Duane, Therese M</creatorcontrib><creatorcontrib>Evans, Heather L</creatorcontrib><creatorcontrib>Cook, Charles H</creatorcontrib><creatorcontrib>O’Neill, Patrick J</creatorcontrib><creatorcontrib>Mazuski, John E</creatorcontrib><creatorcontrib>Askari, Reza</creatorcontrib><creatorcontrib>Wilson, Mark A</creatorcontrib><creatorcontrib>Napolitano, Lena M</creatorcontrib><creatorcontrib>Namias, Nicholas</creatorcontrib><creatorcontrib>Miller, Preston R</creatorcontrib><creatorcontrib>Dellinger, E. Patchen</creatorcontrib><creatorcontrib>Watson, Christopher M</creatorcontrib><creatorcontrib>Coimbra, Raul</creatorcontrib><creatorcontrib>Dent, Daniel L</creatorcontrib><creatorcontrib>Lowry, Stephen F</creatorcontrib><creatorcontrib>Cocanour, Christine S</creatorcontrib><creatorcontrib>West, Michaela A</creatorcontrib><creatorcontrib>Banton, Kaysie L</creatorcontrib><creatorcontrib>Cheadle, William G</creatorcontrib><creatorcontrib>Lipsett, Pamela A</creatorcontrib><creatorcontrib>Guidry, Christopher A</creatorcontrib><creatorcontrib>Popovsky, Kimberley</creatorcontrib><creatorcontrib>STOP-IT Trial Investigators</creatorcontrib><title>Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>This randomized, controlled trial involving patients with complicated intraabdominal infections and proper source control showed similar outcomes after fixed-duration antimicrobial therapy (4 days) and after a longer course (approximately 8 days).
Complicated intraabdominal infection continues to be a common problem worldwide. Approximately 300,000 cases of appendicitis occur each year in the United States,
1
and at least twice that many cases of non-appendiceal infection require management.
2
Morbidity ranges from 5% among patients evaluated in broad observational studies
2
–
4
to close to 50% in some cohorts, such as the elderly or critically ill.
5
,
6
Despite the diversity of specific processes in these infections, the basic tenets of management are similar: resuscitate patients who have the systemic inflammatory response syndrome (SIRS), control the source of contamination, remove most of the infected or necrotic material, . . .</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Appendicitis</subject><subject>Appendicitis - drug therapy</subject><subject>Drug Administration Schedule</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Fever</subject><subject>Fever - etiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Intraabdominal Infections - complications</subject><subject>Intraabdominal Infections - drug therapy</subject><subject>Intraabdominal Infections - mortality</subject><subject>Kaplan-Meier Estimate</subject><subject>Leukocytosis</subject><subject>Leukocytosis - etiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medication Adherence</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Peritonitis - etiology</subject><subject>Recurrence</subject><subject>Recurrent infection</subject><subject>Sepsis - drug therapy</subject><subject>Surgical site infections</subject><subject>Surgical Wound Infection - etiology</subject><subject>Young Adult</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kUtLAzEUhYMoWqtLtzIggpvRvGeyEUrxUfGxsK5DksnYlJlJTaaC_96UqljBu7mL83G49xwAjhA8R5Dxi8eruwevEEUIcbwFBogRklMK-TYYQIjLnBaC7IH9GOcwDaJiF-xhJgQuKB-A22lwqsl8nT3PfOjzsV-GaLNR17vWmeD1Sp3ObFCLj6z2IZt0fVBKV751XZImXW1N73x3AHZq1UR7-LWH4OX6ajq-ze-fbibj0X1uGEJ9LgpjTK2N0RoxYStKSKkxK5mqoa4EZ6awwnJWwUowWiFlMBG1FtyWGDJLyBBcrn0XS93aytjVPY1cBNeq8CG9cnJT6dxMvvp3SSkXqMTJ4OzLIPi3pY29bF00tmlUZ_0ySsRLXAoohEjoyR90nuJJb68pSktOikTlayrFFWOw9c8xCMpVR3Kjo8Qf__7gh_4uJQGna6Bto-zsvP3H6BP7M5kS</recordid><startdate>20150521</startdate><enddate>20150521</enddate><creator>Sawyer, Robert G</creator><creator>Claridge, Jeffrey A</creator><creator>Nathens, Avery B</creator><creator>Rotstein, Ori D</creator><creator>Duane, Therese M</creator><creator>Evans, Heather L</creator><creator>Cook, Charles H</creator><creator>O’Neill, Patrick J</creator><creator>Mazuski, John E</creator><creator>Askari, Reza</creator><creator>Wilson, Mark A</creator><creator>Napolitano, Lena M</creator><creator>Namias, Nicholas</creator><creator>Miller, Preston R</creator><creator>Dellinger, E. 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Patchen ; Watson, Christopher M ; Coimbra, Raul ; Dent, Daniel L ; Lowry, Stephen F ; Cocanour, Christine S ; West, Michaela A ; Banton, Kaysie L ; Cheadle, William G ; Lipsett, Pamela A ; Guidry, Christopher A ; Popovsky, Kimberley</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-97cccfbccbb159ed4338b2585af0bd965c7e9e65d0d954d1ac239fb96e8205e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Appendicitis</topic><topic>Appendicitis - drug therapy</topic><topic>Drug Administration Schedule</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Fever</topic><topic>Fever - etiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Intraabdominal Infections - complications</topic><topic>Intraabdominal Infections - drug therapy</topic><topic>Intraabdominal Infections - mortality</topic><topic>Kaplan-Meier Estimate</topic><topic>Leukocytosis</topic><topic>Leukocytosis - etiology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medication Adherence</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Peritonitis - etiology</topic><topic>Recurrence</topic><topic>Recurrent infection</topic><topic>Sepsis - drug therapy</topic><topic>Surgical site infections</topic><topic>Surgical Wound Infection - etiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sawyer, Robert G</creatorcontrib><creatorcontrib>Claridge, Jeffrey A</creatorcontrib><creatorcontrib>Nathens, Avery B</creatorcontrib><creatorcontrib>Rotstein, Ori D</creatorcontrib><creatorcontrib>Duane, Therese M</creatorcontrib><creatorcontrib>Evans, Heather L</creatorcontrib><creatorcontrib>Cook, Charles H</creatorcontrib><creatorcontrib>O’Neill, Patrick J</creatorcontrib><creatorcontrib>Mazuski, John E</creatorcontrib><creatorcontrib>Askari, Reza</creatorcontrib><creatorcontrib>Wilson, Mark A</creatorcontrib><creatorcontrib>Napolitano, Lena M</creatorcontrib><creatorcontrib>Namias, Nicholas</creatorcontrib><creatorcontrib>Miller, Preston R</creatorcontrib><creatorcontrib>Dellinger, E. 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Patchen</au><au>Watson, Christopher M</au><au>Coimbra, Raul</au><au>Dent, Daniel L</au><au>Lowry, Stephen F</au><au>Cocanour, Christine S</au><au>West, Michaela A</au><au>Banton, Kaysie L</au><au>Cheadle, William G</au><au>Lipsett, Pamela A</au><au>Guidry, Christopher A</au><au>Popovsky, Kimberley</au><aucorp>STOP-IT Trial Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2015-05-21</date><risdate>2015</risdate><volume>372</volume><issue>21</issue><spage>1996</spage><epage>2005</epage><pages>1996-2005</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><abstract>This randomized, controlled trial involving patients with complicated intraabdominal infections and proper source control showed similar outcomes after fixed-duration antimicrobial therapy (4 days) and after a longer course (approximately 8 days).
Complicated intraabdominal infection continues to be a common problem worldwide. Approximately 300,000 cases of appendicitis occur each year in the United States,
1
and at least twice that many cases of non-appendiceal infection require management.
2
Morbidity ranges from 5% among patients evaluated in broad observational studies
2
–
4
to close to 50% in some cohorts, such as the elderly or critically ill.
5
,
6
Despite the diversity of specific processes in these infections, the basic tenets of management are similar: resuscitate patients who have the systemic inflammatory response syndrome (SIRS), control the source of contamination, remove most of the infected or necrotic material, . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>25992746</pmid><doi>10.1056/NEJMoa1411162</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
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| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4469182 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - administration & dosage Antibiotics Antimicrobial agents Appendicitis Appendicitis - drug therapy Drug Administration Schedule Drug therapy Female Fever Fever - etiology Humans Infections Intraabdominal Infections - complications Intraabdominal Infections - drug therapy Intraabdominal Infections - mortality Kaplan-Meier Estimate Leukocytosis Leukocytosis - etiology Male Medical research Medication Adherence Middle Aged Patients Peritonitis - etiology Recurrence Recurrent infection Sepsis - drug therapy Surgical site infections Surgical Wound Infection - etiology Young Adult |
| title | Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection |
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