Adolescent endogenous sex hormones and breast density in early adulthood
During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for bre...
Gespeichert in:
| Veröffentlicht in: | Breast cancer research : BCR 2015-06, Vol.17 (1), p.77-77, Article 77 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 77 |
|---|---|
| container_issue | 1 |
| container_start_page | 77 |
| container_title | Breast cancer research : BCR |
| container_volume | 17 |
| creator | Jung, Seungyoun Egleston, Brian L Chandler, D Walt Van Horn, Linda Hylton, Nola M Klifa, Catherine C Lasser, Norman L LeBlanc, Erin S Paris, Kenneth Shepherd, John A Snetselaar, Linda G Stanczyk, Frank Z Stevens, Victor J Dorgan, Joanne F |
| description | During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer.
Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV.
Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all P trend ≤0.03) but not when measured in postmenarche samples (all P trend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all P trend ≥0.16).
Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown.
ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999. |
| doi_str_mv | 10.1186/s13058-015-0581-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4468804</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A541592861</galeid><sourcerecordid>A541592861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-4d44a16bef8436d7c2aaa8e472b6275ee1a7d97d8a5adffb548dbb3706694e5e3</originalsourceid><addsrcrecordid>eNptUcFq3DAUFKWhSdN-QC9F0EsuTvRsSZYvhSWkTSHQSwu9iWfreVfFllLJW7p_X5lNQwJFhyeeZoYZDWPvQFwCGH2VoRHKVAJUVSZU8gU7A6lVpWT94-WT-yl7nfNPIaA1yrxip7UWErSCM3a7cXGiPFBYOAUXtxTiPvNMf_gupjkGyhyD430izAt3FLJfDtwHTpimA0e3n5ZdjO4NOxlxyvT2YZ6z759uvl3fVndfP3-53txVg9R6qaSTEkH3NBrZaNcONSIakm3d67pVRICt61pnUKEbx15J4_q-aYXWnSRFzTn7eNS93_czudV4wsneJz9jOtiI3j5_CX5nt_G3lVIbI2QRuHgQSPHXnvJiZ1_yTxMGKtEtaNPpGmTTFeiHI3SLE1kfxlgUhxVuN0qC6mqjoaAu_4Mqx9Hsh_KDoy_7ZwQ4EoYUc040ProHYddi7bFYW4q1a7F2df3-aexHxr8mm78YOZ9k</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1689621439</pqid></control><display><type>article</type><title>Adolescent endogenous sex hormones and breast density in early adulthood</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Jung, Seungyoun ; Egleston, Brian L ; Chandler, D Walt ; Van Horn, Linda ; Hylton, Nola M ; Klifa, Catherine C ; Lasser, Norman L ; LeBlanc, Erin S ; Paris, Kenneth ; Shepherd, John A ; Snetselaar, Linda G ; Stanczyk, Frank Z ; Stevens, Victor J ; Dorgan, Joanne F</creator><creatorcontrib>Jung, Seungyoun ; Egleston, Brian L ; Chandler, D Walt ; Van Horn, Linda ; Hylton, Nola M ; Klifa, Catherine C ; Lasser, Norman L ; LeBlanc, Erin S ; Paris, Kenneth ; Shepherd, John A ; Snetselaar, Linda G ; Stanczyk, Frank Z ; Stevens, Victor J ; Dorgan, Joanne F</creatorcontrib><description>During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer.
Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV.
Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all P trend ≤0.03) but not when measured in postmenarche samples (all P trend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all P trend ≥0.16).
Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown.
ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.</description><identifier>ISSN: 1465-542X</identifier><identifier>ISSN: 1465-5411</identifier><identifier>EISSN: 1465-542X</identifier><identifier>DOI: 10.1186/s13058-015-0581-4</identifier><identifier>PMID: 26041651</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adolescent ; Adult ; Analysis ; Breast - metabolism ; Breast - pathology ; Breast Neoplasms - blood ; Child ; Dehydroepiandrosterone ; Dehydroepiandrosterone Sulfate - blood ; Dehydroepiandrosterone Sulfate - metabolism ; Estrogen ; Female ; Gonadal Steroid Hormones - blood ; Gonadal Steroid Hormones - metabolism ; Health aspects ; Hormones ; Humans ; Magnetic Resonance Imaging ; Physiological aspects ; Progesterone ; Risk Factors ; Sex Hormone-Binding Globulin - metabolism ; Sulfates ; Testosterone</subject><ispartof>Breast cancer research : BCR, 2015-06, Vol.17 (1), p.77-77, Article 77</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Jung et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-4d44a16bef8436d7c2aaa8e472b6275ee1a7d97d8a5adffb548dbb3706694e5e3</citedby><cites>FETCH-LOGICAL-c466t-4d44a16bef8436d7c2aaa8e472b6275ee1a7d97d8a5adffb548dbb3706694e5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468804/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468804/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26041651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Seungyoun</creatorcontrib><creatorcontrib>Egleston, Brian L</creatorcontrib><creatorcontrib>Chandler, D Walt</creatorcontrib><creatorcontrib>Van Horn, Linda</creatorcontrib><creatorcontrib>Hylton, Nola M</creatorcontrib><creatorcontrib>Klifa, Catherine C</creatorcontrib><creatorcontrib>Lasser, Norman L</creatorcontrib><creatorcontrib>LeBlanc, Erin S</creatorcontrib><creatorcontrib>Paris, Kenneth</creatorcontrib><creatorcontrib>Shepherd, John A</creatorcontrib><creatorcontrib>Snetselaar, Linda G</creatorcontrib><creatorcontrib>Stanczyk, Frank Z</creatorcontrib><creatorcontrib>Stevens, Victor J</creatorcontrib><creatorcontrib>Dorgan, Joanne F</creatorcontrib><title>Adolescent endogenous sex hormones and breast density in early adulthood</title><title>Breast cancer research : BCR</title><addtitle>Breast Cancer Res</addtitle><description>During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer.
Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV.
Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all P trend ≤0.03) but not when measured in postmenarche samples (all P trend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all P trend ≥0.16).
Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown.
ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis</subject><subject>Breast - metabolism</subject><subject>Breast - pathology</subject><subject>Breast Neoplasms - blood</subject><subject>Child</subject><subject>Dehydroepiandrosterone</subject><subject>Dehydroepiandrosterone Sulfate - blood</subject><subject>Dehydroepiandrosterone Sulfate - metabolism</subject><subject>Estrogen</subject><subject>Female</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Gonadal Steroid Hormones - metabolism</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Physiological aspects</subject><subject>Progesterone</subject><subject>Risk Factors</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>Sulfates</subject><subject>Testosterone</subject><issn>1465-542X</issn><issn>1465-5411</issn><issn>1465-542X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUcFq3DAUFKWhSdN-QC9F0EsuTvRsSZYvhSWkTSHQSwu9iWfreVfFllLJW7p_X5lNQwJFhyeeZoYZDWPvQFwCGH2VoRHKVAJUVSZU8gU7A6lVpWT94-WT-yl7nfNPIaA1yrxip7UWErSCM3a7cXGiPFBYOAUXtxTiPvNMf_gupjkGyhyD430izAt3FLJfDtwHTpimA0e3n5ZdjO4NOxlxyvT2YZ6z759uvl3fVndfP3-53txVg9R6qaSTEkH3NBrZaNcONSIakm3d67pVRICt61pnUKEbx15J4_q-aYXWnSRFzTn7eNS93_czudV4wsneJz9jOtiI3j5_CX5nt_G3lVIbI2QRuHgQSPHXnvJiZ1_yTxMGKtEtaNPpGmTTFeiHI3SLE1kfxlgUhxVuN0qC6mqjoaAu_4Mqx9Hsh_KDoy_7ZwQ4EoYUc040ProHYddi7bFYW4q1a7F2df3-aexHxr8mm78YOZ9k</recordid><startdate>20150604</startdate><enddate>20150604</enddate><creator>Jung, Seungyoun</creator><creator>Egleston, Brian L</creator><creator>Chandler, D Walt</creator><creator>Van Horn, Linda</creator><creator>Hylton, Nola M</creator><creator>Klifa, Catherine C</creator><creator>Lasser, Norman L</creator><creator>LeBlanc, Erin S</creator><creator>Paris, Kenneth</creator><creator>Shepherd, John A</creator><creator>Snetselaar, Linda G</creator><creator>Stanczyk, Frank Z</creator><creator>Stevens, Victor J</creator><creator>Dorgan, Joanne F</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150604</creationdate><title>Adolescent endogenous sex hormones and breast density in early adulthood</title><author>Jung, Seungyoun ; Egleston, Brian L ; Chandler, D Walt ; Van Horn, Linda ; Hylton, Nola M ; Klifa, Catherine C ; Lasser, Norman L ; LeBlanc, Erin S ; Paris, Kenneth ; Shepherd, John A ; Snetselaar, Linda G ; Stanczyk, Frank Z ; Stevens, Victor J ; Dorgan, Joanne F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-4d44a16bef8436d7c2aaa8e472b6275ee1a7d97d8a5adffb548dbb3706694e5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis</topic><topic>Breast - metabolism</topic><topic>Breast - pathology</topic><topic>Breast Neoplasms - blood</topic><topic>Child</topic><topic>Dehydroepiandrosterone</topic><topic>Dehydroepiandrosterone Sulfate - blood</topic><topic>Dehydroepiandrosterone Sulfate - metabolism</topic><topic>Estrogen</topic><topic>Female</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Gonadal Steroid Hormones - metabolism</topic><topic>Health aspects</topic><topic>Hormones</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Physiological aspects</topic><topic>Progesterone</topic><topic>Risk Factors</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>Sulfates</topic><topic>Testosterone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Seungyoun</creatorcontrib><creatorcontrib>Egleston, Brian L</creatorcontrib><creatorcontrib>Chandler, D Walt</creatorcontrib><creatorcontrib>Van Horn, Linda</creatorcontrib><creatorcontrib>Hylton, Nola M</creatorcontrib><creatorcontrib>Klifa, Catherine C</creatorcontrib><creatorcontrib>Lasser, Norman L</creatorcontrib><creatorcontrib>LeBlanc, Erin S</creatorcontrib><creatorcontrib>Paris, Kenneth</creatorcontrib><creatorcontrib>Shepherd, John A</creatorcontrib><creatorcontrib>Snetselaar, Linda G</creatorcontrib><creatorcontrib>Stanczyk, Frank Z</creatorcontrib><creatorcontrib>Stevens, Victor J</creatorcontrib><creatorcontrib>Dorgan, Joanne F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Breast cancer research : BCR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Seungyoun</au><au>Egleston, Brian L</au><au>Chandler, D Walt</au><au>Van Horn, Linda</au><au>Hylton, Nola M</au><au>Klifa, Catherine C</au><au>Lasser, Norman L</au><au>LeBlanc, Erin S</au><au>Paris, Kenneth</au><au>Shepherd, John A</au><au>Snetselaar, Linda G</au><au>Stanczyk, Frank Z</au><au>Stevens, Victor J</au><au>Dorgan, Joanne F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adolescent endogenous sex hormones and breast density in early adulthood</atitle><jtitle>Breast cancer research : BCR</jtitle><addtitle>Breast Cancer Res</addtitle><date>2015-06-04</date><risdate>2015</risdate><volume>17</volume><issue>1</issue><spage>77</spage><epage>77</epage><pages>77-77</pages><artnum>77</artnum><issn>1465-542X</issn><issn>1465-5411</issn><eissn>1465-542X</eissn><abstract>During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer.
Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988 to 1997. They had sex hormones and sex hormone-binding globulin (SHBG) measured in serum collected on one to five occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV.
Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all P trend ≤0.03) but not when measured in postmenarche samples (all P trend ≥0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7 to 22.1 % and from 14.1 to 24.3 %, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre- or postmenarche serum samples were not associated with %DBV (all P trend ≥0.16).
Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown.
ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>26041651</pmid><doi>10.1186/s13058-015-0581-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1465-542X |
| ispartof | Breast cancer research : BCR, 2015-06, Vol.17 (1), p.77-77, Article 77 |
| issn | 1465-542X 1465-5411 1465-542X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4468804 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Analysis Breast - metabolism Breast - pathology Breast Neoplasms - blood Child Dehydroepiandrosterone Dehydroepiandrosterone Sulfate - blood Dehydroepiandrosterone Sulfate - metabolism Estrogen Female Gonadal Steroid Hormones - blood Gonadal Steroid Hormones - metabolism Health aspects Hormones Humans Magnetic Resonance Imaging Physiological aspects Progesterone Risk Factors Sex Hormone-Binding Globulin - metabolism Sulfates Testosterone |
| title | Adolescent endogenous sex hormones and breast density in early adulthood |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T08%3A56%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adolescent%20endogenous%20sex%20hormones%20and%20breast%20density%20in%20early%20adulthood&rft.jtitle=Breast%20cancer%20research%20:%20BCR&rft.au=Jung,%20Seungyoun&rft.date=2015-06-04&rft.volume=17&rft.issue=1&rft.spage=77&rft.epage=77&rft.pages=77-77&rft.artnum=77&rft.issn=1465-542X&rft.eissn=1465-542X&rft_id=info:doi/10.1186/s13058-015-0581-4&rft_dat=%3Cgale_pubme%3EA541592861%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1689621439&rft_id=info:pmid/26041651&rft_galeid=A541592861&rfr_iscdi=true |