Sequential combination therapy with pegylated interferon leads to loss of hepatitis B surface antigen and hepatitis B e antigen (HBeAg) seroconversion in HBeAg-positive chronic hepatitis B patients receiving long-term entecavir treatment

Nucleos(t)ide analogues rarely result in a durable off-treatment response in chronic hepatitis B infection, whereas pegylated interferon (Peg-IFN) induces a long-lasting response only in a subset of patients. We assessed the effect of sequential combination therapy with Peg-IFN-α2a and entecavir in...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-07, Vol.59 (7), p.4121-4128
Hauptverfasser:	Li, Guo-Jun, Yu, Yi-Qi, Chen, Shao-Long, Fan, Ping, Shao, Ling-Yun, Chen, Jia-Zhen, Li, Chang-Shui, Yi, Bin, Chen, Wei-Cun, Xie, Shu-Yuan, Mao, Xiao-Na, Zou, He-Hui, Zhang, Wen-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antiviral Agents Antiviral Agents - therapeutic use Area Under Curve Endpoint Determination Female Guanine Guanine - analogs & derivatives Guanine - therapeutic use Hepatitis B e Antigens Hepatitis B e Antigens - immunology Hepatitis B Surface Antigens Hepatitis B Surface Antigens - immunology Hepatitis B virus Hepatitis B, Chronic Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - immunology Hepatitis B, Chronic - virology Humans Interferon-alpha Interferon-alpha - therapeutic use Male Middle Aged Polyethylene Glycols Polyethylene Glycols - therapeutic use Predictive Value of Tests Recombinant Proteins - therapeutic use Retrospective Studies Seroconversion Treatment Outcome Young Adult
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