Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin

Metformin, the most widely prescribed antidiabetic drug, requires transporters to enter tissues involved in its pharmacologic action, including liver, kidney, and peripheral tissues. Organic cation transporter 3 (OCT3, SLC22A3), expressed ubiquitously, transports metformin, but its in vivo role in m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 2015-07, Vol.88 (1), p.75-83
Hauptverfasser:	Chen, Eugene C., Liang, Xiaomin, Yee, Sook Wah, Geier, Ethan G., Stocker, Sophie L., Chen, Ligong, Giacomini, Kathleen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Adipose Tissue - metabolism Animals Biological Availability Cell Line, Tumor Gene Expression Regulation - drug effects Glucose - metabolism HCT116 Cells Healthy Volunteers Hep G2 Cells Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - pharmacokinetics Injections, Intraperitoneal Male Metformin - administration & dosage Metformin - pharmacokinetics Mice Mice, Knockout Muscle, Skeletal - metabolism Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism Polymorphism, Single Nucleotide Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!