Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy

A key barrier against developing preventive and therapeutic human immunodeficiency virus (HIV) vaccines is the inability of viral envelope glycoproteins to elicit broad and potent neutralizing antibodies. However, in the presence of fusion inhibitor enfuvirtide, we show that the nonneutralizing anti...

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Veröffentlicht in:	Journal of virology 2015-07, Vol.89 (13), p.6960-6964
Hauptverfasser:	Wang, Qian, Bi, Wenwen, Zhu, Xiaojie, Li, Haoyang, Qi, Qianqian, Yu, Fei, Lu, Lu, Jiang, Shibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing - immunology HIV Antibodies - immunology HIV Envelope Protein gp41 - immunology HIV Envelope Protein gp41 - pharmacology HIV Fusion Inhibitors - pharmacology HIV-1 - drug effects HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Mice Neutralization Tests Peptide Fragments - pharmacology Rabbits Vaccines and Antiviral Agents
Online-Zugang:	Volltext
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