Impact of iron overload and potential benefit from iron chelation in low-risk myelodysplastic syndrome

Myelodysplastic syndromes (MDSs) are a group of heterogeneous clonal bone marrow disorders characterized by ineffective hematopoiesis, peripheral blood cytopenias, and potential for malignant transformation. Lower/intermediate-risk MDSs are associated with longer survival and high red blood cell (RB...

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Veröffentlicht in:	Blood 2014-08, Vol.124 (6), p.873-881
Hauptverfasser:	Shenoy, Niraj, Vallumsetla, Nishanth, Rachmilewitz, Eliezer, Verma, Amit, Ginzburg, Yelena
Format:	Artikel
Sprache:	eng
Schlagworte:	Chelation Therapy Erythrocyte Transfusion - adverse effects Erythrocytes - metabolism Erythropoiesis Hepcidins - blood Humans Iron - blood Iron - metabolism Iron Chelating Agents - therapeutic use Iron Overload - blood Iron Overload - drug therapy Iron Overload - etiology Models, Biological Myelodysplastic Syndromes - blood Myelodysplastic Syndromes - complications Myelodysplastic Syndromes - therapy Review Risk Factors
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