Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers

The objective of this study was to investigate the insulin incorporation and release properties of poly(methacrylic acid- g-ethylene glycol) P(MAA- g-EG) microparticles as a function of copolymer composition. These microparticles exhibited unique pH-responsive characteristics in which interpolymer c...

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Veröffentlicht in:	Journal of controlled release 2002-05, Vol.81 (1), p.25-32
Hauptverfasser:	Morishita, Mariko, Lowman, Anthony M., Takayama, Kozo, Nagai, Tsuneji, Peppas, Nicholas A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Complexation polymers Controlled release Delayed-Action Preparations - pharmacokinetics Drug Carriers - pharmacokinetics General pharmacology Hormones. Endocrine system Hypoglycemic Agents - pharmacokinetics Insulin Insulin - pharmacokinetics Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers - pharmacokinetics
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