Cissus quadrangularis inhibits IL-1β induced inflammatory responses on chondrocytes and alleviates bone deterioration in osteotomized rats via p38 MAPK signaling

Inflammatory mediators are key players in the pathogenesis of osteoarthritis (OA) and bone destruction. Conventional drugs suppress symptomatic activity and have no therapeutic influence on disease. Cissus quadrangularis and Withania somnifera are widely used for the treatment of bone fractures and...

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Veröffentlicht in:	Drug design, development and therapy development and therapy, 2015-01, Vol.9, p.2927-2940
Hauptverfasser:	Kanwar, Jagat R, Samarasinghe, Rasika M, Kumar, Kuldeep, Arya, Ramesh, Sharma, Sanjeev, Zhou, Shu-Feng, Sasidharan, Sreenivasan, Kanwar, Rupinder K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase alternative therapy Animals Anti-Inflammatory Agents - pharmacology Arthritis Biocompatibility Biomedical materials Bone Diseases - prevention & control Cancer therapies Care and treatment Cartilage Cartilage cells Cartilage diseases Cell culture Cell death Cell Survival Cell viability Cellular signal transduction Chondrocytes Chondrocytes - drug effects Chronic illnesses Cissus Cissus - chemistry Cissus quadrangularis Cytokines Destruction Drug dosages Female Fractures Gene expression Gene Expression - drug effects Genetic aspects Glycosaminoglycans - metabolism Growth factors Health aspects herbal Humans IL-1β Inflammation Inflammation - chemically induced Inflammation - prevention & control Interleukin-1 Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - toxicity Interleukins Kinases Male MAP kinase Matrix metalloproteinase Matrix metalloproteinases Medical research Medicinal plants Molecular modelling Nitric Oxide - metabolism Original Research Osteoarthritis Osteogenesis Osteotomy p38 Mitogen-Activated Protein Kinases - physiology Pathogenesis Phosphatase Plant Extracts - pharmacology Primary Cell Culture Proteins Rats Reagents Rheumatic diseases Signal transduction Signal Transduction - drug effects Signaling Survival Survivin TNF inhibitors Toxicity Tumor necrosis factor-TNF Withania somnifera
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