SOX9 was involved in TKIs resistance in renal cell carcinoma via Raf/MEK/ERK signaling pathway

Renal cell carcinoma (RCC) is common genitourinary malignancy in human, 30-40% of patients with RCC would be diagnosed with metastatic RCC (mRCC). Even in the era of targeted therapy, patients with mRCC would inevitably progress due to drug resistance. Herein, exploration of the mechanisms of resist...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2015-01, Vol.8 (4), p.3871-3881
Hauptverfasser:	Li, Xing-Lan, Chen, Xue-Qin, Zhang, Meng-Ni, Chen, Ni, Nie, Ling, Xu, Miao, Gong, Jing, Shen, Peng-Fei, Su, Zheng-Zheng, Weng, Xin, Tan, Jun-Ya, Zhao, Tao, Zeng, Hao, Zhou, Qiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Line, Tumor Female Humans Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Male MAP Kinase Signaling System - physiology Original Protein Kinase Inhibitors - therapeutic use Protein-Tyrosine Kinases - antagonists & inhibitors raf Kinases - metabolism Signal Transduction - physiology SOX9 Transcription Factor - metabolism
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