Selective conversion of fibroblasts into peripheral sensory neurons

In this study, the authors show that expression of Brn3a with Ngn1 or 2 can induce the direct reprogramming of mouse and human fibroblasts into peripheral sensory neurons. They further demonstrate that these neurons exhibit the expression profiles and physiological properties of mature sensory neuro...

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Veröffentlicht in:	Nature neuroscience 2015-01, Vol.18 (1), p.25-35
Hauptverfasser:	Blanchard, Joel W, Eade, Kevin T, Szűcs, Attila, Lo Sardo, Valentina, Tsunemoto, Rachel K, Williams, Daniel, Sanna, Pietro Paolo, Baldwin, Kristin K
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 14 14/63 38 631/378/2571/2573 631/378/2620/410 631/532/2435 Animal Genetics and Genomics Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology Behavioral Sciences Biological Techniques Biomedicine Female Fibroblasts Fibroblasts - physiology Fibroblasts - ultrastructure Gene expression Genetic aspects Histamine Humans Mice Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neurobiology Neurons Neurosciences Nociceptors - ultrastructure Pain Patch-Clamp Techniques Peripheral Nervous System - cytology Peripheral Nervous System - ultrastructure Physiological aspects Pregnancy Receptor, trkC - genetics Sensory Receptor Cells - physiology Sensory Receptor Cells - ultrastructure Sensory receptors Transcription Factor Brn-3A - genetics Transcription Factor Brn-3A - physiology Transcription factors
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