Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

Using human bladder cancer xenograft models, a new mechanism involving an active proliferative response of cancer stem cells to chemotherapy-induced damage is shown, driven by prostaglandin E 2 (PGE 2 ) release in a manner similar to PGE 2 -induced wound repair; pharmacological inhibition of the PGE...

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Veröffentlicht in:	Nature (London) 2015-01, Vol.517 (7533), p.209-213
Hauptverfasser:	Kurtova, Antonina V., Xiao, Jing, Mo, Qianxing, Pazhanisamy, Senthil, Krasnow, Ross, Lerner, Seth P., Chen, Fengju, Roh, Terrence T., Lay, Erica, Ho, Philip Levy, Chan, Keith Syson
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/100 13/106 13/109 13/2 13/21 13/31 13/44 14/1 14/63 631/67/71 64/60 Animals Antibodies, Neutralizing - immunology Antibodies, Neutralizing - pharmacology Apoptosis - drug effects Celecoxib Cell Proliferation - drug effects Cyclooxygenase 2 - metabolism Cyclooxygenase 2 Inhibitors - pharmacology Dinoprostone - antagonists & inhibitors Dinoprostone - immunology Dinoprostone - metabolism Dinoprostone - secretion Drug Resistance, Neoplasm - drug effects Female Humanities and Social Sciences Humans letter Male Mice multidisciplinary Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Pyrazoles - pharmacology Science Signal Transduction - drug effects Sulfonamides - pharmacology Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Wound Healing - genetics Xenograft Model Antitumor Assays
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