Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice

Background Contact toxicant reactions are accompanied by localized skin inflammation and concomitant increases in site-specific itch responses. The role(s) of eosinophils in these reactions is poorly understood. However, previous studies have suggested that localized eosinophil-nerve interactions at...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2015-02, Vol.135 (2), p.477-487.e1
Hauptverfasser:	Lee, James J., PhD, Protheroe, Cheryl A., BA, Luo, Huijun, PhD, Ochkur, Sergei I., PhD, Scott, Gregory D., BS, Zellner, Katie R., MS, Raish, Randall J., MS, Dahl, Mark V., MD, Vega, Miriam L., MD, MPH, Conley, Olivia, Condjella, Rachel M., PhD, Kloeber, Jake A, Neely, Joseph L, Patel, Yash S, Maizer, Patty, MS, Mazzolini, Andrew, MA, Fryer, Allison D., PhD, Jacoby, Noah W, Jacoby, David B., MD, Lee, Nancy A., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens - administration & dosage Allergens - immunology Allergies Allergy and Immunology Animals Biopsy Cell Degranulation Collagen Collagen - metabolism Contact hypersensitivity degranulation Dermatitis Dinitrofluorobenzene - administration & dosage Dinitrofluorobenzene - adverse effects Disease Models, Animal eosinophil-deficient Eosinophilia - immunology Eosinophilia - metabolism Eosinophilia - pathology Eosinophils - immunology Eosinophils - metabolism Fibrosis Histology Histopathology Inflammation - immunology Inflammation - metabolism Inflammation - pathology Laboratories Mice Phthalic Anhydrides - administration & dosage Phthalic Anhydrides - adverse effects Phthalic Anhydrides - immunology Pruritus - diagnosis Pruritus - etiology Rodents sensory nerve Skin - drug effects Skin - immunology Skin - innervation Skin - pathology Studies Substance P - genetics Substance P - metabolism
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