Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells
Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP...
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| Veröffentlicht in: | Molecular medicine reports 2015-08, Vol.12 (2), p.2650-2660 |
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| creator | LIM, KYUNG MI AN, SUNGKWAN LEE, OK-KYU LEE, MYUNG JOO LEE, JEONG PYO LEE, KWANG SIK LEE, GHANG TAI LEE, KUN KOOK BAE, SEUNGHEE |
| description | Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the balding population. In the present study, troxerutin, a flavonoid derivative of rutin, was demonstrated to have a protective effect against H2O2-mediated cellular damage in human DP (HDP) cells. Biochemical assays revealed that pretreatment with troxerutin exerted a protective effect against H2O2-induced loss of cell viability and H2O2 induced cell death. Further experiments confirmed that troxerutin inhibited the H2O2-induced production of ROS and upregulation of senescence-associated β-galactosidase activity. Using microRNA (miRNA) microarrays, the present study identified 24 miRNAs, which were differentially expressed in the troxerutin pretreated, H2O2-treated HDP cells. Subsequent prediction using bioinformatics analysis revealed that the altered miRNAs were functionally involved in several cell signaling pathways, including the mitogen-activated protein kinase and WNT pathways. Overall, these results indicated that ROS-mediated cellular damage was inhibited by troxerutin and suggested that the use of troxerutin may be an effective approach in the treatment of alopecia. |
| doi_str_mv | 10.3892/mmr.2015.3717 |
| format | Article |
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The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the balding population. In the present study, troxerutin, a flavonoid derivative of rutin, was demonstrated to have a protective effect against H2O2-mediated cellular damage in human DP (HDP) cells. Biochemical assays revealed that pretreatment with troxerutin exerted a protective effect against H2O2-induced loss of cell viability and H2O2 induced cell death. Further experiments confirmed that troxerutin inhibited the H2O2-induced production of ROS and upregulation of senescence-associated β-galactosidase activity. Using microRNA (miRNA) microarrays, the present study identified 24 miRNAs, which were differentially expressed in the troxerutin pretreated, H2O2-treated HDP cells. Subsequent prediction using bioinformatics analysis revealed that the altered miRNAs were functionally involved in several cell signaling pathways, including the mitogen-activated protein kinase and WNT pathways. Overall, these results indicated that ROS-mediated cellular damage was inhibited by troxerutin and suggested that the use of troxerutin may be an effective approach in the treatment of alopecia.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2015.3717</identifier><identifier>PMID: 25955790</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Alopecia ; Androgens ; antioxidant effect ; Antioxidants ; Antioxidants - pharmacology ; Baldness ; Bioflavonoids ; Bioinformatics ; Care and treatment ; Cell adhesion & migration ; Cell cycle ; Cell death ; Cell Line ; Cell Survival - drug effects ; Cellular signal transduction ; dermal papilla cells ; Dermis - cytology ; Dermis - drug effects ; Dermis - metabolism ; Flavones ; Flavonoids ; Genetic aspects ; Hair ; Hair Follicle - cytology ; Hair Follicle - drug effects ; Hair Follicle - metabolism ; Health aspects ; Humans ; Hydrogen peroxide ; Hydrogen Peroxide - metabolism ; Hydroxyethylrutoside - analogs & derivatives ; Hydroxyethylrutoside - pharmacology ; Insulin ; Kinases ; MAP kinase ; Metabolism ; MicroRNA ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; Oxidative stress ; Population studies ; Prostate cancer ; Protein kinase ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Rutin ; Senescence ; Skin ; Transcriptome - drug effects ; troxerutin ; Wnt protein ; β-Galactosidase</subject><ispartof>Molecular medicine reports, 2015-08, Vol.12 (2), p.2650-2660</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><rights>Copyright © 2015, Spandidos Publications 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-23f4563e034b0d9026c9f1cd845dd99cd2826d3f96202973b2394f6bd94553573</citedby><cites>FETCH-LOGICAL-c514t-23f4563e034b0d9026c9f1cd845dd99cd2826d3f96202973b2394f6bd94553573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25955790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIM, KYUNG MI</creatorcontrib><creatorcontrib>AN, SUNGKWAN</creatorcontrib><creatorcontrib>LEE, OK-KYU</creatorcontrib><creatorcontrib>LEE, MYUNG JOO</creatorcontrib><creatorcontrib>LEE, JEONG PYO</creatorcontrib><creatorcontrib>LEE, KWANG SIK</creatorcontrib><creatorcontrib>LEE, GHANG TAI</creatorcontrib><creatorcontrib>LEE, KUN KOOK</creatorcontrib><creatorcontrib>BAE, SEUNGHEE</creatorcontrib><title>Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the balding population. In the present study, troxerutin, a flavonoid derivative of rutin, was demonstrated to have a protective effect against H2O2-mediated cellular damage in human DP (HDP) cells. Biochemical assays revealed that pretreatment with troxerutin exerted a protective effect against H2O2-induced loss of cell viability and H2O2 induced cell death. Further experiments confirmed that troxerutin inhibited the H2O2-induced production of ROS and upregulation of senescence-associated β-galactosidase activity. Using microRNA (miRNA) microarrays, the present study identified 24 miRNAs, which were differentially expressed in the troxerutin pretreated, H2O2-treated HDP cells. Subsequent prediction using bioinformatics analysis revealed that the altered miRNAs were functionally involved in several cell signaling pathways, including the mitogen-activated protein kinase and WNT pathways. Overall, these results indicated that ROS-mediated cellular damage was inhibited by troxerutin and suggested that the use of troxerutin may be an effective approach in the treatment of alopecia.</description><subject>Alopecia</subject><subject>Androgens</subject><subject>antioxidant effect</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Baldness</subject><subject>Bioflavonoids</subject><subject>Bioinformatics</subject><subject>Care and treatment</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Cell death</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cellular signal transduction</subject><subject>dermal papilla cells</subject><subject>Dermis - cytology</subject><subject>Dermis - drug effects</subject><subject>Dermis - metabolism</subject><subject>Flavones</subject><subject>Flavonoids</subject><subject>Genetic aspects</subject><subject>Hair</subject><subject>Hair Follicle - cytology</subject><subject>Hair Follicle - drug effects</subject><subject>Hair Follicle - metabolism</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Hydroxyethylrutoside - analogs & derivatives</subject><subject>Hydroxyethylrutoside - pharmacology</subject><subject>Insulin</subject><subject>Kinases</subject><subject>MAP kinase</subject><subject>Metabolism</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>miRNA</subject><subject>Oxidative stress</subject><subject>Population studies</subject><subject>Prostate cancer</subject><subject>Protein kinase</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Rutin</subject><subject>Senescence</subject><subject>Skin</subject><subject>Transcriptome - drug effects</subject><subject>troxerutin</subject><subject>Wnt protein</subject><subject>β-Galactosidase</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptksuKFDEUhgtRnIsu3UrAhW6qzT2VjdAMOgqDgug6pCtJd4ZUUiZVQ88z-NKm6LZ1RAI5IfnOn5ycv2leILgincRvhyGvMERsRQQSj5pzJCRqCYT08XGNpRRnzUUptxByhpl82pzVmTEh4Xnzcx11uC--gORAv9NxawvwEQy-z-nr5zWw-zHbUnyKYMzJ-XA4r3tjisWCKYFpV0NOe5vnycd2sMbryRqg4-TT3psagXXO9tOSuZsHHYGxedABjHr0IWjQ2xDKs-aJ06HY58d42Xz_8P7b1cf25sv1p6v1TdszRKcWE0cZJxYSuoFGQsx76VBvOsqMkbI3uMPcECc5hlgKssFEUsc3RlLGCBPksnl30B3nTX1sb-OUdVBj9oPO9ypprx6eRL9T23SnKOWUIlIF3hwFcvox2zKpwZelBB1tmotCvBNSctTJir76B71Nc65_XilJMBW4Nu8PtdXBKh9dqvf2i6haU8y4oILjSq3-Q9VhbG1XinbpzsOE9pBQe1lKtu5UI4JqcY-q7lGLe9Tinsq__PtjTvRvu1Tg9QEoo47Gm1ROTFVqEW4hbjFnkPwCdyjOTA</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>LIM, KYUNG MI</creator><creator>AN, SUNGKWAN</creator><creator>LEE, OK-KYU</creator><creator>LEE, MYUNG JOO</creator><creator>LEE, JEONG PYO</creator><creator>LEE, KWANG SIK</creator><creator>LEE, GHANG TAI</creator><creator>LEE, KUN KOOK</creator><creator>BAE, SEUNGHEE</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150801</creationdate><title>Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells</title><author>LIM, KYUNG MI ; AN, SUNGKWAN ; LEE, OK-KYU ; LEE, MYUNG JOO ; LEE, JEONG PYO ; LEE, KWANG SIK ; LEE, GHANG TAI ; LEE, KUN KOOK ; BAE, SEUNGHEE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-23f4563e034b0d9026c9f1cd845dd99cd2826d3f96202973b2394f6bd94553573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alopecia</topic><topic>Androgens</topic><topic>antioxidant effect</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Baldness</topic><topic>Bioflavonoids</topic><topic>Bioinformatics</topic><topic>Care and treatment</topic><topic>Cell adhesion & migration</topic><topic>Cell cycle</topic><topic>Cell death</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Cellular signal transduction</topic><topic>dermal papilla cells</topic><topic>Dermis - cytology</topic><topic>Dermis - drug effects</topic><topic>Dermis - metabolism</topic><topic>Flavones</topic><topic>Flavonoids</topic><topic>Genetic aspects</topic><topic>Hair</topic><topic>Hair Follicle - cytology</topic><topic>Hair Follicle - drug effects</topic><topic>Hair Follicle - metabolism</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Hydroxyethylrutoside - analogs & derivatives</topic><topic>Hydroxyethylrutoside - pharmacology</topic><topic>Insulin</topic><topic>Kinases</topic><topic>MAP kinase</topic><topic>Metabolism</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>miRNA</topic><topic>Oxidative stress</topic><topic>Population studies</topic><topic>Prostate cancer</topic><topic>Protein kinase</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Rutin</topic><topic>Senescence</topic><topic>Skin</topic><topic>Transcriptome - drug effects</topic><topic>troxerutin</topic><topic>Wnt protein</topic><topic>β-Galactosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIM, KYUNG MI</creatorcontrib><creatorcontrib>AN, SUNGKWAN</creatorcontrib><creatorcontrib>LEE, OK-KYU</creatorcontrib><creatorcontrib>LEE, MYUNG JOO</creatorcontrib><creatorcontrib>LEE, JEONG PYO</creatorcontrib><creatorcontrib>LEE, KWANG SIK</creatorcontrib><creatorcontrib>LEE, GHANG TAI</creatorcontrib><creatorcontrib>LEE, KUN KOOK</creatorcontrib><creatorcontrib>BAE, SEUNGHEE</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIM, KYUNG MI</au><au>AN, SUNGKWAN</au><au>LEE, OK-KYU</au><au>LEE, MYUNG JOO</au><au>LEE, JEONG PYO</au><au>LEE, KWANG SIK</au><au>LEE, GHANG TAI</au><au>LEE, KUN KOOK</au><au>BAE, SEUNGHEE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>12</volume><issue>2</issue><spage>2650</spage><epage>2660</epage><pages>2650-2660</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the balding population. In the present study, troxerutin, a flavonoid derivative of rutin, was demonstrated to have a protective effect against H2O2-mediated cellular damage in human DP (HDP) cells. Biochemical assays revealed that pretreatment with troxerutin exerted a protective effect against H2O2-induced loss of cell viability and H2O2 induced cell death. Further experiments confirmed that troxerutin inhibited the H2O2-induced production of ROS and upregulation of senescence-associated β-galactosidase activity. Using microRNA (miRNA) microarrays, the present study identified 24 miRNAs, which were differentially expressed in the troxerutin pretreated, H2O2-treated HDP cells. Subsequent prediction using bioinformatics analysis revealed that the altered miRNAs were functionally involved in several cell signaling pathways, including the mitogen-activated protein kinase and WNT pathways. Overall, these results indicated that ROS-mediated cellular damage was inhibited by troxerutin and suggested that the use of troxerutin may be an effective approach in the treatment of alopecia.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25955790</pmid><doi>10.3892/mmr.2015.3717</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Molecular medicine reports, 2015-08, Vol.12 (2), p.2650-2660 |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alopecia Androgens antioxidant effect Antioxidants Antioxidants - pharmacology Baldness Bioflavonoids Bioinformatics Care and treatment Cell adhesion & migration Cell cycle Cell death Cell Line Cell Survival - drug effects Cellular signal transduction dermal papilla cells Dermis - cytology Dermis - drug effects Dermis - metabolism Flavones Flavonoids Genetic aspects Hair Hair Follicle - cytology Hair Follicle - drug effects Hair Follicle - metabolism Health aspects Humans Hydrogen peroxide Hydrogen Peroxide - metabolism Hydroxyethylrutoside - analogs & derivatives Hydroxyethylrutoside - pharmacology Insulin Kinases MAP kinase Metabolism MicroRNA MicroRNAs MicroRNAs - genetics miRNA Oxidative stress Population studies Prostate cancer Protein kinase Reactive oxygen species Reactive Oxygen Species - metabolism Rutin Senescence Skin Transcriptome - drug effects troxerutin Wnt protein β-Galactosidase |
| title | Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells |
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