Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population
Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (...
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| Veröffentlicht in: | Scientific reports 2015-06, Vol.5 (1), p.11396-11396, Article 11396 |
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| creator | Wu, Vin-Cent Huang, Kuo-How Peng, Kang-Yung Tsai, Yao-Chou Wu, Che-Hsiung Wang, Shuo-Meng Yang, Shao-Yu Lin, Lian-Yu Chang, Chin-Chen Lin, Yen-Hung Lin, Shuei-Liong Chu, Tzong-Shinn Wu, Kwan-Dun |
| description | Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n = 91, 61.5%); including mutations in
KCNJ5
(n = 88, 59.5%),
ATP1A1
(n = 2, 1.4%) and
ATP2B3
(n = 1, 0.7%); however, no mutations in
CACNA1D
were identified. Mutation-carriers were younger ( |
| doi_str_mv | 10.1038/srep11396 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4464349</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1899509480</sourcerecordid><originalsourceid>FETCH-LOGICAL-c504t-272d1653f397b954bac97bc8e687184a901c4156644cfc4e087e1879b14713313</originalsourceid><addsrcrecordid>eNplkV9rFTEQxYMottQ--AUk4IsVtmY22WzyIpRS_0BBH-pzyM3OXlOyyZrsVvz2pt56udq8zMD55cwMh5CXwM6BcfWuZJwBuJZPyHHLRNe0vG2fHvRH5LSUW1Zf12oB-jk5aiWTkms4JuFrxjsbMDqkNg7UBR-9s4G6lDMGu2ChaaQlTXbxjk7rUmuK1Edqw5DKgjlFpHNOw-p83FI7YKxwc2P9TxuxVC3Na_jz6wV5NtpQ8PShnpBvH65uLj81118-fr68uG5cx8TStH07gOz4yHW_0Z3YWFcbp1CqHpSwmoET0EkphBudQKZ6BNXrDYgeOAd-Qt7vfOd1M-HgMC7ZBjNnP9n8yyTrzb9K9N_NNt0ZIaTgQleDNw8GOf1YsSxm8sVhCPWitBYDUmkOAPIeff0fepvWHOt5BpTWHdNCsUqd7SiXU6mJjftlgJn7GM0-xsq-Otx-T_4NrQJvd0CpUtxiPhj5yO03OXOoDQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1899509480</pqid></control><display><type>article</type><title>Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population</title><source>Nature Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Wu, Vin-Cent ; Huang, Kuo-How ; Peng, Kang-Yung ; Tsai, Yao-Chou ; Wu, Che-Hsiung ; Wang, Shuo-Meng ; Yang, Shao-Yu ; Lin, Lian-Yu ; Chang, Chin-Chen ; Lin, Yen-Hung ; Lin, Shuei-Liong ; Chu, Tzong-Shinn ; Wu, Kwan-Dun</creator><creatorcontrib>Wu, Vin-Cent ; Huang, Kuo-How ; Peng, Kang-Yung ; Tsai, Yao-Chou ; Wu, Che-Hsiung ; Wang, Shuo-Meng ; Yang, Shao-Yu ; Lin, Lian-Yu ; Chang, Chin-Chen ; Lin, Yen-Hung ; Lin, Shuei-Liong ; Chu, Tzong-Shinn ; Wu, Kwan-Dun</creatorcontrib><description>Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n = 91, 61.5%); including mutations in
KCNJ5
(n = 88, 59.5%),
ATP1A1
(n = 2, 1.4%) and
ATP2B3
(n = 1, 0.7%); however, no mutations in
CACNA1D
were identified. Mutation-carriers were younger (<0.001), had lower Cyst C (p = 0.042), pulse wave velocity (p = 0.027), C-reactive protein (p = 0.042) and a lower rate of proteinuria (p = 0.031) than non-carriers. After multivariate adjustment, mutation carriers had lower serum CRP levels than non-carriers (p = 0.031. Patients with mutation also had a greater chance of recovery from hypertension after operation (p = 0.005). A high incidence of somatic mutations in APA was identified in the Taiwanese population. Mutation-carriers had lower CRP levels and a higher rate of cure of hypertension after adrenalectomy. This raises the possibility of using mutation screening as a tool in predicting long-term outcome after adrenalectomy.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep11396</identifier><identifier>PMID: 26066391</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38 ; 38/23 ; 692/163/2743/1279 ; 692/420/2489/1512 ; 692/499 ; Adenoma ; Adenoma - blood ; Adenoma - epidemiology ; Adenoma - genetics ; Adrenalectomy ; Adult ; Age Factors ; Aged ; Aldosterone ; Aldosterone - metabolism ; C-reactive protein ; Calcium channels ; Channelopathy ; Endocrine disorders ; Female ; G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics ; G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism ; Humanities and Social Sciences ; Humans ; Hyperaldosteronism - blood ; Hyperaldosteronism - epidemiology ; Hyperaldosteronism - genetics ; Hypertension ; Male ; Middle Aged ; multidisciplinary ; Mutation ; Neoplasm Proteins - genetics ; Neoplasm Proteins - metabolism ; Plasma Membrane Calcium-Transporting ATPases - genetics ; Plasma Membrane Calcium-Transporting ATPases - metabolism ; Prevalence ; Proteinuria ; Science ; Sodium-Potassium-Exchanging ATPase - genetics ; Sodium-Potassium-Exchanging ATPase - metabolism ; Taiwan - epidemiology ; Tumors ; Velocity</subject><ispartof>Scientific reports, 2015-06, Vol.5 (1), p.11396-11396, Article 11396</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Jun 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-272d1653f397b954bac97bc8e687184a901c4156644cfc4e087e1879b14713313</citedby><cites>FETCH-LOGICAL-c504t-272d1653f397b954bac97bc8e687184a901c4156644cfc4e087e1879b14713313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464349/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464349/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,41101,42170,51557,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26066391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Vin-Cent</creatorcontrib><creatorcontrib>Huang, Kuo-How</creatorcontrib><creatorcontrib>Peng, Kang-Yung</creatorcontrib><creatorcontrib>Tsai, Yao-Chou</creatorcontrib><creatorcontrib>Wu, Che-Hsiung</creatorcontrib><creatorcontrib>Wang, Shuo-Meng</creatorcontrib><creatorcontrib>Yang, Shao-Yu</creatorcontrib><creatorcontrib>Lin, Lian-Yu</creatorcontrib><creatorcontrib>Chang, Chin-Chen</creatorcontrib><creatorcontrib>Lin, Yen-Hung</creatorcontrib><creatorcontrib>Lin, Shuei-Liong</creatorcontrib><creatorcontrib>Chu, Tzong-Shinn</creatorcontrib><creatorcontrib>Wu, Kwan-Dun</creatorcontrib><title>Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n = 91, 61.5%); including mutations in
KCNJ5
(n = 88, 59.5%),
ATP1A1
(n = 2, 1.4%) and
ATP2B3
(n = 1, 0.7%); however, no mutations in
CACNA1D
were identified. Mutation-carriers were younger (<0.001), had lower Cyst C (p = 0.042), pulse wave velocity (p = 0.027), C-reactive protein (p = 0.042) and a lower rate of proteinuria (p = 0.031) than non-carriers. After multivariate adjustment, mutation carriers had lower serum CRP levels than non-carriers (p = 0.031. Patients with mutation also had a greater chance of recovery from hypertension after operation (p = 0.005). A high incidence of somatic mutations in APA was identified in the Taiwanese population. Mutation-carriers had lower CRP levels and a higher rate of cure of hypertension after adrenalectomy. This raises the possibility of using mutation screening as a tool in predicting long-term outcome after adrenalectomy.</description><subject>38</subject><subject>38/23</subject><subject>692/163/2743/1279</subject><subject>692/420/2489/1512</subject><subject>692/499</subject><subject>Adenoma</subject><subject>Adenoma - blood</subject><subject>Adenoma - epidemiology</subject><subject>Adenoma - genetics</subject><subject>Adrenalectomy</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aldosterone</subject><subject>Aldosterone - metabolism</subject><subject>C-reactive protein</subject><subject>Calcium channels</subject><subject>Channelopathy</subject><subject>Endocrine disorders</subject><subject>Female</subject><subject>G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics</subject><subject>G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hyperaldosteronism - blood</subject><subject>Hyperaldosteronism - epidemiology</subject><subject>Hyperaldosteronism - genetics</subject><subject>Hypertension</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Mutation</subject><subject>Neoplasm Proteins - genetics</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Plasma Membrane Calcium-Transporting ATPases - genetics</subject><subject>Plasma Membrane Calcium-Transporting ATPases - metabolism</subject><subject>Prevalence</subject><subject>Proteinuria</subject><subject>Science</subject><subject>Sodium-Potassium-Exchanging ATPase - genetics</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><subject>Taiwan - epidemiology</subject><subject>Tumors</subject><subject>Velocity</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkV9rFTEQxYMottQ--AUk4IsVtmY22WzyIpRS_0BBH-pzyM3OXlOyyZrsVvz2pt56udq8zMD55cwMh5CXwM6BcfWuZJwBuJZPyHHLRNe0vG2fHvRH5LSUW1Zf12oB-jk5aiWTkms4JuFrxjsbMDqkNg7UBR-9s4G6lDMGu2ChaaQlTXbxjk7rUmuK1Edqw5DKgjlFpHNOw-p83FI7YKxwc2P9TxuxVC3Na_jz6wV5NtpQ8PShnpBvH65uLj81118-fr68uG5cx8TStH07gOz4yHW_0Z3YWFcbp1CqHpSwmoET0EkphBudQKZ6BNXrDYgeOAd-Qt7vfOd1M-HgMC7ZBjNnP9n8yyTrzb9K9N_NNt0ZIaTgQleDNw8GOf1YsSxm8sVhCPWitBYDUmkOAPIeff0fepvWHOt5BpTWHdNCsUqd7SiXU6mJjftlgJn7GM0-xsq-Otx-T_4NrQJvd0CpUtxiPhj5yO03OXOoDQ</recordid><startdate>20150612</startdate><enddate>20150612</enddate><creator>Wu, Vin-Cent</creator><creator>Huang, Kuo-How</creator><creator>Peng, Kang-Yung</creator><creator>Tsai, Yao-Chou</creator><creator>Wu, Che-Hsiung</creator><creator>Wang, Shuo-Meng</creator><creator>Yang, Shao-Yu</creator><creator>Lin, Lian-Yu</creator><creator>Chang, Chin-Chen</creator><creator>Lin, Yen-Hung</creator><creator>Lin, Shuei-Liong</creator><creator>Chu, Tzong-Shinn</creator><creator>Wu, Kwan-Dun</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150612</creationdate><title>Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population</title><author>Wu, Vin-Cent ; Huang, Kuo-How ; Peng, Kang-Yung ; Tsai, Yao-Chou ; Wu, Che-Hsiung ; Wang, Shuo-Meng ; Yang, Shao-Yu ; Lin, Lian-Yu ; Chang, Chin-Chen ; Lin, Yen-Hung ; Lin, Shuei-Liong ; Chu, Tzong-Shinn ; Wu, Kwan-Dun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-272d1653f397b954bac97bc8e687184a901c4156644cfc4e087e1879b14713313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>38</topic><topic>38/23</topic><topic>692/163/2743/1279</topic><topic>692/420/2489/1512</topic><topic>692/499</topic><topic>Adenoma</topic><topic>Adenoma - blood</topic><topic>Adenoma - epidemiology</topic><topic>Adenoma - genetics</topic><topic>Adrenalectomy</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aldosterone</topic><topic>Aldosterone - metabolism</topic><topic>C-reactive protein</topic><topic>Calcium channels</topic><topic>Channelopathy</topic><topic>Endocrine disorders</topic><topic>Female</topic><topic>G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics</topic><topic>G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hyperaldosteronism - blood</topic><topic>Hyperaldosteronism - epidemiology</topic><topic>Hyperaldosteronism - genetics</topic><topic>Hypertension</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Mutation</topic><topic>Neoplasm Proteins - genetics</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Plasma Membrane Calcium-Transporting ATPases - genetics</topic><topic>Plasma Membrane Calcium-Transporting ATPases - metabolism</topic><topic>Prevalence</topic><topic>Proteinuria</topic><topic>Science</topic><topic>Sodium-Potassium-Exchanging ATPase - genetics</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><topic>Taiwan - epidemiology</topic><topic>Tumors</topic><topic>Velocity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Vin-Cent</creatorcontrib><creatorcontrib>Huang, Kuo-How</creatorcontrib><creatorcontrib>Peng, Kang-Yung</creatorcontrib><creatorcontrib>Tsai, Yao-Chou</creatorcontrib><creatorcontrib>Wu, Che-Hsiung</creatorcontrib><creatorcontrib>Wang, Shuo-Meng</creatorcontrib><creatorcontrib>Yang, Shao-Yu</creatorcontrib><creatorcontrib>Lin, Lian-Yu</creatorcontrib><creatorcontrib>Chang, Chin-Chen</creatorcontrib><creatorcontrib>Lin, Yen-Hung</creatorcontrib><creatorcontrib>Lin, Shuei-Liong</creatorcontrib><creatorcontrib>Chu, Tzong-Shinn</creatorcontrib><creatorcontrib>Wu, Kwan-Dun</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Vin-Cent</au><au>Huang, Kuo-How</au><au>Peng, Kang-Yung</au><au>Tsai, Yao-Chou</au><au>Wu, Che-Hsiung</au><au>Wang, Shuo-Meng</au><au>Yang, Shao-Yu</au><au>Lin, Lian-Yu</au><au>Chang, Chin-Chen</au><au>Lin, Yen-Hung</au><au>Lin, Shuei-Liong</au><au>Chu, Tzong-Shinn</au><au>Wu, Kwan-Dun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-06-12</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>11396</spage><epage>11396</epage><pages>11396-11396</pages><artnum>11396</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently described in aldosterone-producing adenoma (APA). The study involved 148 consecutive PA patients, (66 males; aged 56.3 ± 12.3years) who received adrenalectomy and were collected from the Taiwan PA investigator (TAIPAI) group. A high rate of somatic mutation in APA was found (n = 91, 61.5%); including mutations in
KCNJ5
(n = 88, 59.5%),
ATP1A1
(n = 2, 1.4%) and
ATP2B3
(n = 1, 0.7%); however, no mutations in
CACNA1D
were identified. Mutation-carriers were younger (<0.001), had lower Cyst C (p = 0.042), pulse wave velocity (p = 0.027), C-reactive protein (p = 0.042) and a lower rate of proteinuria (p = 0.031) than non-carriers. After multivariate adjustment, mutation carriers had lower serum CRP levels than non-carriers (p = 0.031. Patients with mutation also had a greater chance of recovery from hypertension after operation (p = 0.005). A high incidence of somatic mutations in APA was identified in the Taiwanese population. Mutation-carriers had lower CRP levels and a higher rate of cure of hypertension after adrenalectomy. This raises the possibility of using mutation screening as a tool in predicting long-term outcome after adrenalectomy.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26066391</pmid><doi>10.1038/srep11396</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 38 38/23 692/163/2743/1279 692/420/2489/1512 692/499 Adenoma Adenoma - blood Adenoma - epidemiology Adenoma - genetics Adrenalectomy Adult Age Factors Aged Aldosterone Aldosterone - metabolism C-reactive protein Calcium channels Channelopathy Endocrine disorders Female G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism Humanities and Social Sciences Humans Hyperaldosteronism - blood Hyperaldosteronism - epidemiology Hyperaldosteronism - genetics Hypertension Male Middle Aged multidisciplinary Mutation Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Plasma Membrane Calcium-Transporting ATPases - genetics Plasma Membrane Calcium-Transporting ATPases - metabolism Prevalence Proteinuria Science Sodium-Potassium-Exchanging ATPase - genetics Sodium-Potassium-Exchanging ATPase - metabolism Taiwan - epidemiology Tumors Velocity |
| title | Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population |
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