Vitamin D3 inhibits lipopolysaccharide-induced placental inflammation through reinforcing interaction between vitamin D receptor and nuclear factor kappa B p65 subunit

It is increasingly recognized that vitamin D3 (VitD3) has an anti-inflammatory activity. The present study investigated the effects of maternal VitD3 supplementation during pregnancy on LPS-induced placental inflammation and fetal intrauterine growth restriction (IUGR). All pregnant mice except cont...

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Veröffentlicht in:	Scientific reports 2015-06, Vol.5 (1), p.10871-10871, Article 10871
Hauptverfasser:	Chen, Yuan-Hua, Yu, Zhen, Fu, Lin, Wang, Hua, Chen, Xue, Zhang, Cheng, Lv, Zheng-Mei, Xu, De-Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 631/136/3194 631/250/516/1909 64/60 82/51 82/80 Animals Anti-inflammatory agents Cholecalciferol - pharmacology Female Fetal Growth Retardation - chemically induced Fetal Growth Retardation - drug therapy Fetal Growth Retardation - metabolism Fetal Growth Retardation - pathology Fetuses Gene expression Humanities and Social Sciences Inflammation Inflammation - chemically induced Inflammation - drug therapy Inflammation - metabolism Inflammation - pathology Lipopolysaccharides Lipopolysaccharides - toxicity Male Mice Mice, Inbred ICR multidisciplinary Nuclear transport Oral administration Placenta Placenta - metabolism Placenta - pathology Placenta Diseases - chemically induced Placenta Diseases - drug therapy Placenta Diseases - metabolism Placenta Diseases - pathology Pregnancy Receptors, Calcitriol - metabolism Rodents Science Signal Transduction - drug effects Supplements Transcription Factor RelA - metabolism Translocation Vitamin D Vitamin D receptors Vitamin D3
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