Mitochondria-derived reactive oxygen species play an important role in Doxorubicin-induced platelet apoptosis

Doxorubicin (DOX) is an effective chemotherapeutic agent; however; its use is limited by some side effects; such as cardiotoxicity and thrombocytopenia. DOX-induced cardiotoxicity has been intensively investigated; however; DOX-induced thrombocytopenia has not been clearly elucidated. Here we show t...

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Veröffentlicht in:	International journal of molecular sciences 2015-05, Vol.16 (5), p.11087-11100
Hauptverfasser:	Wang, Zhicheng, Wang, Jie, Xie, Rufeng, Liu, Ruilai, Lu, Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics, Antineoplastic - pharmacology Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Blood platelets Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - metabolism Cardiolipins - metabolism Caspase 3 - metabolism Cytochromes c - metabolism Doxorubicin - pharmacology Female Humans Lipid Peroxidation - drug effects Male Malondialdehyde - metabolism Membrane Potential, Mitochondrial - drug effects Mitochondria Mitochondria - drug effects Mitochondria - metabolism Oxidative Stress - drug effects Oxygen Platelet Aggregation - drug effects Platelet Glycoprotein GPIb-IX Complex - metabolism Reactive Oxygen Species - metabolism von Willebrand Factor - metabolism
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