L1014F-kdr Mutation in Indian Anopheles subpictus (Diptera: Culicidae) Arising from Two Alternative Transversions in the Voltage-Gated Sodium Channel and a Single PIRA-PCR for Their Detection

Leucine-to-phenylalanine substitution at residue L1014 in the voltage-gated sodium channel, target site of action for dichlorodiphenyltrichloroethane (DDT) and pyrethroids, is the most common knockdown resistance (kdr) mutation reported in several insects conferring resistance against DDT and pyreth...

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Veröffentlicht in:	Journal of medical entomology 2015-01, Vol.52 (1), p.24-27
Hauptverfasser:	Singh, O. P., Dykes, C. L., Sharma, G., Das, M. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Anopheles - genetics Anopheles - metabolism Anopheles subpictus DDT (pesticide) Female Gene Frequency genotyping India Insect Proteins - genetics Insect Proteins - metabolism insecticide resistance insects knockdown resistance malaria MOLECULAR BIOLOGY/GENOMICS Molecular Sequence Data Point Mutation Polymerase Chain Reaction pyrethrins Sequence Analysis, DNA sodium channel sodium channels Voltage-Gated Sodium Channels - genetics Voltage-Gated Sodium Channels - metabolism
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