Alterations in frontal white matter neurochemistry and microstructure in schizophrenia: implications for neuroinflammation

We investigated in vivo neurochemical markers reflective of neuronal health and glial activation to determine if these could yield clues regarding the reduced fractional anisotropy (FA) of white matter and accelerated decline of FA with age in schizophrenia. Participants with schizophrenia and healt...

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Veröffentlicht in:	Translational psychiatry 2015-04, Vol.5 (4), p.e548-e548
Hauptverfasser:	Chiappelli, J, Hong, L E, Wijtenburg, S A, Du, X, Gaston, F, Kochunov, P, Rowland, L M
Format:	Artikel
Sprache:	eng
Schlagworte:	59/57 692/699/476/1799 Adult Age Factors Anisotropy Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Behavioral Sciences Biological Psychology Case-Control Studies Choline - metabolism Creatine - metabolism Diffusion Tensor Imaging Female Frontal Lobe - metabolism Frontal Lobe - pathology Glutamic Acid - metabolism Humans Inflammation Inositol - metabolism Magnetic Resonance Spectroscopy Male Medicine Medicine & Public Health Middle Aged Neuroglia - metabolism Neurosciences Original original-article Pharmacotherapy Psychiatry Schizophrenia - metabolism Schizophrenia - pathology White Matter - metabolism White Matter - pathology Young Adult
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