Prevention of cancer recurrence in tumor margins by stopping microcirculation in the tumor and tumor–host interface

Combretastatins interrupt blood flow of solid tumor vascular networks and lead to necrosis by blocking nutrients. However, tumors recover from tumor blood flow interruption‐induced damage and develop viable rims. To investigate why cancer recurs and its prevention, we used a combretastatin derivativ...

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Veröffentlicht in:Cancer science 2014-09, Vol.105 (9), p.1196-1204
Hauptverfasser: Hori, Katsuyoshi, Akita, Hirotoshi, Nonaka, Hiroi, Sumiyoshi, Akira, Taki, Yasuyuki
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Sprache:eng
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