TET2 as an epigenetic master regulator for normal and malignant hematopoiesis

DNA methylation is one of the critical epigenetic modifications regulating various cellular processes such as differentiation or proliferation, and its dysregulation leads to disordered stem cell function or cellular transformation. The ten‐eleven translocation (TET) gene family, initially found as...

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Veröffentlicht in:	Cancer science 2014-09, Vol.105 (9), p.1093-1099
Hauptverfasser:	Nakajima, Hideaki, Kunimoto, Hiroyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Binding sites Chromatin Chromosomes Cloning Cytosine Cytosine demethylation Demethylation Deoxyribonucleic acid DNA DNA Methylation DNA-Binding Proteins - physiology Epigenesis, Genetic Epigenetics Gene expression Gene Expression Regulation, Neoplastic Genetic transformation Genomes Hematologic Neoplasms - genetics hematological malignancies Hematology Hematopoiesis - genetics Hematopoietic stem cells Homeostasis Humans Isocitrate dehydrogenase Leukemia Lymphoma MicroRNAs Mutation Myelodysplastic syndrome N-Acetylglucosamine Proteins Proto-Oncogene Proteins - physiology Review Stem cell transplantation Stem cells TET2 Tumors
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