SS18‐SSX‐regulated miR‐17 promotes tumor growth of synovial sarcoma by inhibiting p21WAF1/CIP1

MicroRNA (miRNA) can function as tumor suppressors or oncogenes, and also as potential specific cancer biomarkers; however, there are few published studies on miRNA in synovial sarcomas, and their function remains unclear. We transfected the OncomiR miRNA Precursor Virus Library into synovial sarcom...

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Veröffentlicht in:	Cancer science 2014-09, Vol.105 (9), p.1152-1159
Hauptverfasser:	Minami, Yusuke, Kohsaka, Shinji, Tsuda, Masumi, Yachi, Kazuhiro, Hatori, Nobuaki, Tanino, Mishie, Kimura, Taichi, Nishihara, Hiroshi, Minami, Akio, Iwasaki, Norimasa, Tanaka, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Animals Base Sequence Binding Sites Cell Line, Tumor Cell Proliferation Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Cyclin‐dependent kinase inhibitor p21 drug resistance Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic hsa‐mir‐17 microRNA Humans Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Neoplasm Transplantation Oncogene Proteins, Fusion - physiology Original RNA Interference Sarcoma, Synovial - genetics Sarcoma, Synovial - metabolism Sarcoma, Synovial - pathology SS18‐SSX fusion protein synovial sarcoma
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