Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation

Basal cell carcinoma (BCC) is the most common cancer worldwide, and its current treatment options are insufficient and toxic. Surprisingly, unlike several other malignancies, chemopreventive efforts against BCC are almost lacking. Silibinin, a natural agent from milk thistle seeds, has shown strong...

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Veröffentlicht in:	Molecular carcinogenesis 2016-01, Vol.55 (1), p.3-14
Hauptverfasser:	Tilley, Cynthia, Deep, Gagan, Agarwal, Chapla, Wempe, Michael F., Biedermann, David, Valentová, Kateřina, Kren, Vladimir, Agarwal, Rajesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Allografts Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antioxidants - chemistry Antioxidants - pharmacology Apoptosis - drug effects basal cell carcinoma Cancer therapies Carcinoma, Basal Cell - drug therapy Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Cell Line, Tumor Cell Proliferation - drug effects chemoprevention dehydrosilibinin Disease Models, Animal EGFR Enzyme Activation - drug effects Herbal medicine Humans Mice Mice, Knockout mitogenic signaling NF-kappa B - metabolism phytochemicals Signal Transduction - drug effects silibinin Silymarin - chemistry Silymarin - pharmacology Skin cancer Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Transcription Factor AP-1 - metabolism Transcription factors Transcription Factors - metabolism Tumor Stem Cell Assay
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