Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4

Intraperitoneal injection of the Gram-negative bacterial endotoxin lipopolysaccharide (LPS) elicits a rapid innate immune response. While this systemic inflammatory response can be destructive, tolerable low doses of LPS render the brain transiently resistant to subsequent injuries. However, the mec...

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Veröffentlicht in:	The Journal of neuroscience 2012-08, Vol.32 (34), p.11706-11715
Hauptverfasser:	Chen, Zhihong, Jalabi, Walid, Shpargel, Karl B, Farabaugh, Kenneth T, Dutta, Ranjan, Yin, Xinghua, Kidd, Grahame J, Bergmann, Cornelia C, Stohlman, Stephen A, Trapp, Bruce D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Apoptosis - drug effects Bone Marrow Transplantation Brain Injuries - drug therapy Brain Injuries - pathology Brain Injuries - surgery Bromodeoxyuridine - metabolism Cell Proliferation - drug effects Central Nervous System - cytology Central Nervous System - drug effects Disease Models, Animal Dose-Response Relationship, Drug Drug Administration Schedule Flow Cytometry Immunity, Innate - drug effects In Situ Nick-End Labeling Lipopolysaccharides - administration & dosage Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Microarray Analysis Microglia - drug effects Microglia - metabolism Microglia - ultrastructure Microscopy, Immunoelectron Motor Cortex - pathology Motor Cortex - ultrastructure Neuroprotective Agents - administration & dosage Synapses - genetics Synapses - metabolism Synapses - ultrastructure Toll-Like Receptor 4 - deficiency Toll-Like Receptor 4 - metabolism Transplantation Chimera
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