Maternal use of flaxseed oil during pregnancy and lactation prevents morphological alterations in pancreas of female offspring from rat dams with experimental diabetes
Summary Nutritional recommendations have promoted the increased need to consume n‐3 polyunsaturated fatty acids. Flaxseed is the richest dietary source of n‐3 fatty acids among plant sources and is widely used for its edible oil. This study aimed to investigate whether maternal use of flaxseed oil h...
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| Veröffentlicht in: | International journal of experimental pathology 2015-04, Vol.96 (2), p.94-102 |
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| creator | Correia-Santos, André Manoel Vicente, Gabriela C. Suzuki, Akemi Pereira, Aline D. dos Anjos, Juliana S. Lenzi-Almeida, Kátia C. Boaventura, Gilson T. |
| description | Summary
Nutritional recommendations have promoted the increased need to consume n‐3 polyunsaturated fatty acids. Flaxseed is the richest dietary source of n‐3 fatty acids among plant sources and is widely used for its edible oil. This study aimed to investigate whether maternal use of flaxseed oil has effects on pancreas morphology in the female offspring of diabetic mothers. Female Wistar rats (n = 12) were induced into diabetes by a high‐fat diet and low dose of streptozotocin. After confirmation of the diabetes, rats were mated, and once pregnancy was confirmed, they were allocated into three groups (n = 6): high‐fat group (HG); flaxseed oil group (FOG); and control group (CG) (non‐diabetic rats). At weaning, female offspring (n = 6/group) received standard chow diet. The animals were euthanized at 180 days. Pancreas was collected for histomorphometric and immunohistochemistry analysis. HG showed hypertrophy of pancreatic islets (P |
| doi_str_mv | 10.1111/iep.12126 |
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Nutritional recommendations have promoted the increased need to consume n‐3 polyunsaturated fatty acids. Flaxseed is the richest dietary source of n‐3 fatty acids among plant sources and is widely used for its edible oil. This study aimed to investigate whether maternal use of flaxseed oil has effects on pancreas morphology in the female offspring of diabetic mothers. Female Wistar rats (n = 12) were induced into diabetes by a high‐fat diet and low dose of streptozotocin. After confirmation of the diabetes, rats were mated, and once pregnancy was confirmed, they were allocated into three groups (n = 6): high‐fat group (HG); flaxseed oil group (FOG); and control group (CG) (non‐diabetic rats). At weaning, female offspring (n = 6/group) received standard chow diet. The animals were euthanized at 180 days. Pancreas was collected for histomorphometric and immunohistochemistry analysis. HG showed hypertrophy of pancreatic islets (P < 0.0001), whereas FOG offspring had islets with smaller diameters compared to HG (P < 0.0001). HG offspring showed higher percentage of larger (P = 0.0061) and lower percentage of smaller islets (P = 0.0036). HG showed lower islet insulin immunodensity at 180 days (P < 0.0001), whereas FOG was similar to CG (P < 0.0001). Flaxseed oil reduced the damage caused by maternal hyperglycaemia, promoting normal pancreas histomorphometry and β‐cell mass in female offspring.</description><identifier>ISSN: 0959-9673</identifier><identifier>EISSN: 1365-2613</identifier><identifier>DOI: 10.1111/iep.12126</identifier><identifier>PMID: 25808815</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animals ; Animals, Newborn - metabolism ; diabetes ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - pathology ; Disease Models, Animal ; Female ; flaxseed oil ; gestational ; Hyperglycemia - complications ; Hyperglycemia - metabolism ; Hyperglycemia - pathology ; Hypertrophy - metabolism ; Hypertrophy - pathology ; Hypertrophy - prevention & control ; Insulin - metabolism ; Insulin-Secreting Cells - metabolism ; Insulin-Secreting Cells - pathology ; Lactation - metabolism ; Linseed Oil - metabolism ; Linseed Oil - therapeutic use ; metabolic programming ; Original ; pancreas ; Pancreas - metabolism ; Pancreas - pathology ; Pregnancy ; Pregnancy, Animal - metabolism ; rat ; Rats ; Rats, Wistar ; Streptozocin - adverse effects</subject><ispartof>International journal of experimental pathology, 2015-04, Vol.96 (2), p.94-102</ispartof><rights>2015 The Authors. International Journal of Experimental Pathology © 2015 International Journal of Experimental Pathology</rights><rights>2015 The Authors. International Journal of Experimental Pathology © 2015 International Journal of Experimental Pathology.</rights><rights>2015 The Authors. International Journal of Experimental Pathology © 2015 International Journal of Experimental Pathology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5236-63dcb2314008c01cff502ba9ea9aff17a5e6a9ddd1d5bfc64560db59752159d53</citedby><cites>FETCH-LOGICAL-c5236-63dcb2314008c01cff502ba9ea9aff17a5e6a9ddd1d5bfc64560db59752159d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459801/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459801/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25808815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Correia-Santos, André Manoel</creatorcontrib><creatorcontrib>Vicente, Gabriela C.</creatorcontrib><creatorcontrib>Suzuki, Akemi</creatorcontrib><creatorcontrib>Pereira, Aline D.</creatorcontrib><creatorcontrib>dos Anjos, Juliana S.</creatorcontrib><creatorcontrib>Lenzi-Almeida, Kátia C.</creatorcontrib><creatorcontrib>Boaventura, Gilson T.</creatorcontrib><title>Maternal use of flaxseed oil during pregnancy and lactation prevents morphological alterations in pancreas of female offspring from rat dams with experimental diabetes</title><title>International journal of experimental pathology</title><addtitle>Int. J. Exp. Pathol</addtitle><description>Summary
Nutritional recommendations have promoted the increased need to consume n‐3 polyunsaturated fatty acids. Flaxseed is the richest dietary source of n‐3 fatty acids among plant sources and is widely used for its edible oil. This study aimed to investigate whether maternal use of flaxseed oil has effects on pancreas morphology in the female offspring of diabetic mothers. Female Wistar rats (n = 12) were induced into diabetes by a high‐fat diet and low dose of streptozotocin. After confirmation of the diabetes, rats were mated, and once pregnancy was confirmed, they were allocated into three groups (n = 6): high‐fat group (HG); flaxseed oil group (FOG); and control group (CG) (non‐diabetic rats). At weaning, female offspring (n = 6/group) received standard chow diet. The animals were euthanized at 180 days. Pancreas was collected for histomorphometric and immunohistochemistry analysis. HG showed hypertrophy of pancreatic islets (P < 0.0001), whereas FOG offspring had islets with smaller diameters compared to HG (P < 0.0001). HG offspring showed higher percentage of larger (P = 0.0061) and lower percentage of smaller islets (P = 0.0036). HG showed lower islet insulin immunodensity at 180 days (P < 0.0001), whereas FOG was similar to CG (P < 0.0001). Flaxseed oil reduced the damage caused by maternal hyperglycaemia, promoting normal pancreas histomorphometry and β‐cell mass in female offspring.</description><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes Mellitus, Experimental - pathology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>flaxseed oil</subject><subject>gestational</subject><subject>Hyperglycemia - complications</subject><subject>Hyperglycemia - metabolism</subject><subject>Hyperglycemia - pathology</subject><subject>Hypertrophy - metabolism</subject><subject>Hypertrophy - pathology</subject><subject>Hypertrophy - prevention & control</subject><subject>Insulin - metabolism</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Insulin-Secreting Cells - pathology</subject><subject>Lactation - metabolism</subject><subject>Linseed Oil - metabolism</subject><subject>Linseed Oil - therapeutic use</subject><subject>metabolic programming</subject><subject>Original</subject><subject>pancreas</subject><subject>Pancreas - metabolism</subject><subject>Pancreas - pathology</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - metabolism</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptozocin - adverse effects</subject><issn>0959-9673</issn><issn>1365-2613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ks9uEzEQhy0EoiFw4AWQj_Swrb0b758LEqpKWimBHkAcrVl7nBi868XetMkT8Zo4SRvBAV8s2d98M_LPhLzl7IKndWlxuOA5z8tnZMKLUmR5yYvnZMIa0WRNWRVn5FWMPxjjRc6rl-QsFzWray4m5PcSRgw9OLqJSL2hxsE2ImrqraN6E2y_okPAVQ-92lHoNXWgRhit7_fn99iPkXY-DGvv_MqqZAKXlAciUpuoVBkQ4sGOHbh9HxOHg9oE39EEUw1dpA92XFPcDhhsl8TJpS20OGJ8TV4YcBHfPO5T8u3T9derm2zxZX579XGRKZEXZVYWWrV5wWeM1YpxZYxgeQsNQgPG8AoEltBorbkWrVHlTJRMt6KpRM5Fo0UxJR-O3mHTdqhVmiKAk2nYDsJOerDy35veruXK38vZTDR1euApef8oCP7XBuMoOxsVOgc9-k2UvKxFJVIOTULPj6gKPsaA5tSGM7kPVqZg5SHYxL77e64T-ZRkAi6PwIN1uPu_Sd5e3z0ps2OFjSNuTxUQfsr0ZSohv3-ey-XNYi4WdzO5LP4ATRjCbw</recordid><startdate>201504</startdate><enddate>201504</enddate><creator>Correia-Santos, André Manoel</creator><creator>Vicente, Gabriela C.</creator><creator>Suzuki, Akemi</creator><creator>Pereira, Aline D.</creator><creator>dos Anjos, Juliana S.</creator><creator>Lenzi-Almeida, Kátia C.</creator><creator>Boaventura, Gilson T.</creator><general>Blackwell Publishing Ltd</general><general>BlackWell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201504</creationdate><title>Maternal use of flaxseed oil during pregnancy and lactation prevents morphological alterations in pancreas of female offspring from rat dams with experimental diabetes</title><author>Correia-Santos, André Manoel ; Vicente, Gabriela C. ; Suzuki, Akemi ; Pereira, Aline D. ; dos Anjos, Juliana S. ; Lenzi-Almeida, Kátia C. ; Boaventura, Gilson T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5236-63dcb2314008c01cff502ba9ea9aff17a5e6a9ddd1d5bfc64560db59752159d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes Mellitus, Experimental - pathology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>flaxseed oil</topic><topic>gestational</topic><topic>Hyperglycemia - complications</topic><topic>Hyperglycemia - metabolism</topic><topic>Hyperglycemia - pathology</topic><topic>Hypertrophy - metabolism</topic><topic>Hypertrophy - pathology</topic><topic>Hypertrophy - prevention & control</topic><topic>Insulin - metabolism</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Insulin-Secreting Cells - pathology</topic><topic>Lactation - metabolism</topic><topic>Linseed Oil - metabolism</topic><topic>Linseed Oil - therapeutic use</topic><topic>metabolic programming</topic><topic>Original</topic><topic>pancreas</topic><topic>Pancreas - metabolism</topic><topic>Pancreas - pathology</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - metabolism</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptozocin - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Correia-Santos, André Manoel</creatorcontrib><creatorcontrib>Vicente, Gabriela C.</creatorcontrib><creatorcontrib>Suzuki, Akemi</creatorcontrib><creatorcontrib>Pereira, Aline D.</creatorcontrib><creatorcontrib>dos Anjos, Juliana S.</creatorcontrib><creatorcontrib>Lenzi-Almeida, Kátia C.</creatorcontrib><creatorcontrib>Boaventura, Gilson T.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Correia-Santos, André Manoel</au><au>Vicente, Gabriela C.</au><au>Suzuki, Akemi</au><au>Pereira, Aline D.</au><au>dos Anjos, Juliana S.</au><au>Lenzi-Almeida, Kátia C.</au><au>Boaventura, Gilson T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal use of flaxseed oil during pregnancy and lactation prevents morphological alterations in pancreas of female offspring from rat dams with experimental diabetes</atitle><jtitle>International journal of experimental pathology</jtitle><addtitle>Int. J. Exp. Pathol</addtitle><date>2015-04</date><risdate>2015</risdate><volume>96</volume><issue>2</issue><spage>94</spage><epage>102</epage><pages>94-102</pages><issn>0959-9673</issn><eissn>1365-2613</eissn><abstract>Summary
Nutritional recommendations have promoted the increased need to consume n‐3 polyunsaturated fatty acids. Flaxseed is the richest dietary source of n‐3 fatty acids among plant sources and is widely used for its edible oil. This study aimed to investigate whether maternal use of flaxseed oil has effects on pancreas morphology in the female offspring of diabetic mothers. Female Wistar rats (n = 12) were induced into diabetes by a high‐fat diet and low dose of streptozotocin. After confirmation of the diabetes, rats were mated, and once pregnancy was confirmed, they were allocated into three groups (n = 6): high‐fat group (HG); flaxseed oil group (FOG); and control group (CG) (non‐diabetic rats). At weaning, female offspring (n = 6/group) received standard chow diet. The animals were euthanized at 180 days. Pancreas was collected for histomorphometric and immunohistochemistry analysis. HG showed hypertrophy of pancreatic islets (P < 0.0001), whereas FOG offspring had islets with smaller diameters compared to HG (P < 0.0001). HG offspring showed higher percentage of larger (P = 0.0061) and lower percentage of smaller islets (P = 0.0036). HG showed lower islet insulin immunodensity at 180 days (P < 0.0001), whereas FOG was similar to CG (P < 0.0001). Flaxseed oil reduced the damage caused by maternal hyperglycaemia, promoting normal pancreas histomorphometry and β‐cell mass in female offspring.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25808815</pmid><doi>10.1111/iep.12126</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Animals, Newborn - metabolism diabetes Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - pathology Disease Models, Animal Female flaxseed oil gestational Hyperglycemia - complications Hyperglycemia - metabolism Hyperglycemia - pathology Hypertrophy - metabolism Hypertrophy - pathology Hypertrophy - prevention & control Insulin - metabolism Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Lactation - metabolism Linseed Oil - metabolism Linseed Oil - therapeutic use metabolic programming Original pancreas Pancreas - metabolism Pancreas - pathology Pregnancy Pregnancy, Animal - metabolism rat Rats Rats, Wistar Streptozocin - adverse effects |
| title | Maternal use of flaxseed oil during pregnancy and lactation prevents morphological alterations in pancreas of female offspring from rat dams with experimental diabetes |
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