A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

In response to numerous pathologic stimuli, the myocardium undergoes a hypertrophic response characterized by increased myocardial cell size and activation of fetal cardiac genes. We show that cardiac hypertrophy is induced by the calcium-dependent phosphatase calcineurin, which dephosphorylates the...

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Veröffentlicht in:	Cell 1998-04, Vol.93 (2), p.215-228
Hauptverfasser:	Molkentin, Jeffery D, Lu, Jian-Rong, Antos, Christopher L, Markham, Bruce, Richardson, James, Robbins, Jeffrey, Grant, Stephen R, Olson, Eric N
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Animals, Newborn Atrial Natriuretic Factor - genetics Calcineurin - genetics Calcineurin - physiology Cardiomegaly - enzymology Cardiomegaly - genetics Cardiomegaly - prevention & control Cell Nucleus - metabolism DNA-Binding Proteins - metabolism GATA4 Transcription Factor Immunosuppressive Agents - pharmacology Mice Mice, Transgenic Myocardium - metabolism Myocardium - pathology Natriuretic Peptide, Brain NFATC Transcription Factors Nuclear Proteins Phenylephrine - pharmacology Promoter Regions, Genetic - genetics Rats Recombinant Fusion Proteins Signal Transduction - physiology Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation - physiology Zinc Fingers
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