Toll‐like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin II‐induced hypertension

Background and Purpose Toll‐like receptor 4 (TLR4) signalling contributes to inflammatory cardiovascular diseases, but its role in hypertension and the associated vascular damage is not known. We investigated whether TLR4 activation contributed to angiotensin II (AngII)‐induced hypertension and the...

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Veröffentlicht in:	British journal of pharmacology 2015-06, Vol.172 (12), p.3159-3176
Hauptverfasser:	Hernanz, R, Martínez‐Revelles, S, Palacios, R, Martín, A, Cachofeiro, V, Aguado, A, García‐Redondo, L, Barrús, M T, Batista, P R, Briones, A M, Salaices, M, Alonso, M J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Angiotensin II Angiotensin II - administration & dosage Animals Aorta Aorta - metabolism Blood Pressure Cardiovascular diseases Endothelium, Vascular - pathology Hypertension Hypertension - genetics Hypertension - physiopathology Immunoglobulin G Inflammation - pathology Male Mice Mice, Inbred C57BL Monocyte chemoattractant protein 1 mRNA Muscle contraction Muscle, Smooth, Vascular - metabolism MyD88 protein Myocytes, Smooth Muscle - metabolism NAD(P)H oxidase NF-kappa B - metabolism Oxidative stress Oxidative Stress - physiology Phenylephrine Rats Rats, Inbred SHR Research Papers Reverse Transcriptase Polymerase Chain Reaction Signal transduction Smooth muscle Structure-function relationships Superoxide anions TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Up-Regulation Vascular Remodeling - physiology Western blotting
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