Myeloma cell–derived Runx2 promotes myeloma progression in bone

The progression of multiple myeloma (MM) is governed by a network of molecular signals, the majority of which remain to be identified. Recent studies suggest that Runt-related transcription factor 2 (Runx2), a well-known bone-specific transcription factor, is also expressed in solid tumors, where ex...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood 2015-06, Vol.125 (23), p.3598-3608
Hauptverfasser:	Trotter, Timothy N., Li, Mei, Pan, Qianying, Peker, Deniz, Rowan, Patrick D., Li, Juan, Zhan, Fenghuang, Suva, Larry J., Javed, Amjad, Yang, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta Catenin - genetics beta Catenin - metabolism Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Neoplasms - secondary Cell Line, Tumor Core Binding Factor Alpha 1 Subunit - biosynthesis Core Binding Factor Alpha 1 Subunit - genetics Gene Expression Regulation, Neoplastic Humans Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Lymphoid Neoplasia Mice Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology Neoplasm Metastasis Osteolysis - etiology Osteolysis - genetics Osteolysis - metabolism Osteolysis - pathology Proto-Oncogene Proteins c-akt Repressor Proteins - genetics Repressor Proteins - metabolism Survivin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!