A phenotypic in vitro model for the main determinants of human whole heart function

Abstract This article details the construction and testing of a phenotypic assay system that models in vivo cardiac function in a parallel in vitro environment with human stem cell derived cardiomyocytes. The major determinants of human whole-heart function were experimentally modeled by integrating...

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Veröffentlicht in:	Biomaterials 2015-08, Vol.60, p.20-30
Hauptverfasser:	Stancescu, Maria, Molnar, Peter, McAleer, Christopher W, McLamb, William, Long, Christopher J, Oleaga, Carlota, Prot, Jean-Matthieu, Hickman, James J
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Biomedical materials Cardiomyocyte Cell Culture Techniques - instrumentation Cells, Cultured Cellular Conduction Dentistry Determinants Drug Evaluation, Preclinical - instrumentation Drugs Equipment Design Force generation Functional assay Heart - drug effects Heart - physiology Human Humans In vitro testing Mathematical models Micro-Electrical-Mechanical Systems - instrumentation Microelectrodes Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Serum-free Surgical implants
Online-Zugang:	Volltext
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