Circadian clock genes: Effects on dopamine, reward and addiction
Abstract Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance...
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| Veröffentlicht in: | Alcohol (Fayetteville, N.Y.) N.Y.), 2015-06, Vol.49 (4), p.341-349 |
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| creator | Parekh, Puja K Ozburn, Angela R McClung, Colleen A |
| description | Abstract Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse. |
| doi_str_mv | 10.1016/j.alcohol.2014.09.034 |
| format | Article |
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Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse.</description><identifier>ISSN: 0741-8329</identifier><identifier>EISSN: 1873-6823</identifier><identifier>DOI: 10.1016/j.alcohol.2014.09.034</identifier><identifier>PMID: 25641765</identifier><identifier>CODEN: ALCOEX</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Addiction ; Addictive behaviors ; Alcohol ; Alcoholism - genetics ; Alcoholism - metabolism ; Animals ; Behavior ; Behavior, Addictive - genetics ; Behavior, Addictive - metabolism ; Central Nervous System Depressants - pharmacology ; Circadian ; Circadian Clocks - drug effects ; Circadian Clocks - genetics ; Circadian rhythm ; Circadian Rhythm - drug effects ; Circadian Rhythm - genetics ; Circadian Rhythm Signaling Peptides and Proteins - drug effects ; Circadian Rhythm Signaling Peptides and Proteins - genetics ; Dopamine ; Dopamine - metabolism ; Ethanol - pharmacology ; Gene Expression - drug effects ; Humans ; Kinases ; Mesencephalon - drug effects ; Mesencephalon - metabolism ; Methamphetamine ; Proteins ; Psychiatry ; Reward ; Rodents ; Substance-Related Disorders - genetics ; Substance-Related Disorders - metabolism</subject><ispartof>Alcohol (Fayetteville, N.Y.), 2015-06, Vol.49 (4), p.341-349</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2015</rights><rights>2015 Elsevier Inc. All rights reserved. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c719t-79d893c665847023ffce9dbb839ce2787423a254cb92f8c821cc4806608f39f53</citedby><cites>FETCH-LOGICAL-c719t-79d893c665847023ffce9dbb839ce2787423a254cb92f8c821cc4806608f39f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0741832914201820$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25641765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parekh, Puja K</creatorcontrib><creatorcontrib>Ozburn, Angela R</creatorcontrib><creatorcontrib>McClung, Colleen A</creatorcontrib><title>Circadian clock genes: Effects on dopamine, reward and addiction</title><title>Alcohol (Fayetteville, N.Y.)</title><addtitle>Alcohol</addtitle><description>Abstract Addiction is a widespread public health issue with social and economic ramifications. Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse.</description><subject>Addiction</subject><subject>Addictive behaviors</subject><subject>Alcohol</subject><subject>Alcoholism - genetics</subject><subject>Alcoholism - metabolism</subject><subject>Animals</subject><subject>Behavior</subject><subject>Behavior, Addictive - genetics</subject><subject>Behavior, Addictive - metabolism</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Circadian</subject><subject>Circadian Clocks - drug effects</subject><subject>Circadian Clocks - genetics</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - drug effects</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian Rhythm Signaling Peptides and Proteins - drug effects</subject><subject>Circadian Rhythm Signaling Peptides and Proteins - genetics</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Ethanol - pharmacology</subject><subject>Gene Expression - drug effects</subject><subject>Humans</subject><subject>Kinases</subject><subject>Mesencephalon - drug effects</subject><subject>Mesencephalon - metabolism</subject><subject>Methamphetamine</subject><subject>Proteins</subject><subject>Psychiatry</subject><subject>Reward</subject><subject>Rodents</subject><subject>Substance-Related Disorders - genetics</subject><subject>Substance-Related Disorders - metabolism</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkktvEzEUhS0EoqHwE0AjsWHBDH6NHywKVVQeUiUWwNpyrj2t04kd7Emr_ns8SijQTReWF_7u8T33XIReEtwRTMS7dWdHSJdp7CgmvMO6w4w_QguiJGuFouwxWmDJSasY1UfoWSlrjLGUUj9FR7QXnEjRL9DHZchgXbCxgTHBVXPhoy_vm7Nh8DCVJsXGpa3dhOjfNtnf2OwaG-txLsAUUnyOngx2LP7F4T5GPz-d_Vh-ac-_ff66PD1vQRI9tVI7pRkI0SsuMWXDAF671UoxDZ5KJTlllvYcVpoOChQlAFxhIbAamB56doxO9rrb3WrjHfg4ZTuabQ4bm29NssH8_xLDpblI14bzXgolqsCbg0BOv3a-TGYTCvhxtNGnXTFEcqFUT2tzD6OYKE21nNHX99B12uVYJ2GIUJxijbGqVL-nIKdSsh_u-ibYzHGatTnEaeY4DdamxlnrXv1r-q7qT34V-LAHfB39dfDZFAg-gnch1_yMS-HBL07uKcAYYgA7XvlbX_66MYUabL7POzWvFKneiKKY_QY29saq</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Parekh, Puja K</creator><creator>Ozburn, Angela R</creator><creator>McClung, Colleen A</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>Circadian clock genes: Effects on dopamine, reward and addiction</title><author>Parekh, Puja K ; Ozburn, Angela R ; McClung, Colleen A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c719t-79d893c665847023ffce9dbb839ce2787423a254cb92f8c821cc4806608f39f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Addiction</topic><topic>Addictive behaviors</topic><topic>Alcohol</topic><topic>Alcoholism - 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Substance abuse disorders are often accompanied by disruptions in circadian rhythms including sleep/wake cycles, which can exacerbate symptoms of addiction and dependence. Additionally, genetic disturbance of circadian molecular mechanisms can predispose some individuals to substance abuse disorders. In this review, we will discuss how circadian genes can regulate midbrain dopaminergic activity and subsequently, drug intake and reward. We will also suggest future directions for research on circadian genes and drugs of abuse.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25641765</pmid><doi>10.1016/j.alcohol.2014.09.034</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alcohol (Fayetteville, N.Y.), 2015-06, Vol.49 (4), p.341-349 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Addiction Addictive behaviors Alcohol Alcoholism - genetics Alcoholism - metabolism Animals Behavior Behavior, Addictive - genetics Behavior, Addictive - metabolism Central Nervous System Depressants - pharmacology Circadian Circadian Clocks - drug effects Circadian Clocks - genetics Circadian rhythm Circadian Rhythm - drug effects Circadian Rhythm - genetics Circadian Rhythm Signaling Peptides and Proteins - drug effects Circadian Rhythm Signaling Peptides and Proteins - genetics Dopamine Dopamine - metabolism Ethanol - pharmacology Gene Expression - drug effects Humans Kinases Mesencephalon - drug effects Mesencephalon - metabolism Methamphetamine Proteins Psychiatry Reward Rodents Substance-Related Disorders - genetics Substance-Related Disorders - metabolism |
| title | Circadian clock genes: Effects on dopamine, reward and addiction |
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