A Structural Rearrangement of the Na+/K+-ATPase Traps Ouabain within the External Ion Permeation Pathway

With the use of the energy of ATP hydrolysis, the Na+/K+-ATPase is able to transport across the cell membrane Na+ and K+ against their electrochemical gradients. The enzyme is strongly inhibited by ouabain and its derivatives, some that are therapeutically used for patients with heart failure (cardi...

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Veröffentlicht in:	Journal of molecular biology 2015-03, Vol.427 (6), p.1335-1344
Hauptverfasser:	Sánchez-Rodríguez, Jorge E., Khalili-Araghi, Fatemeh, Miranda, Pablo, Roux, Benoît, Holmgren, Miguel, Bezanilla, Francisco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism adenosine triphosphate Animals cardiotonic steroids Cell Membrane Permeability cell membranes Crystallography, X-Ray Decapodiformes electrochemistry energy transfer Fluorescence Resonance Energy Transfer heart failure hydrolysis ion transport Lanthanoid Series Elements - chemistry membrane protein molecular dynamics Molecular Dynamics Simulation ouabain Ouabain - chemistry Ouabain - metabolism patients potassium Potassium - metabolism Protein Binding Protein Conformation Protein Subunits sodium Sodium - metabolism Sodium-Potassium-Exchanging ATPase - chemistry Sodium-Potassium-Exchanging ATPase - metabolism sodium/potassium pump steroids X-radiation
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