Therapeutic Plasma Exchange in Multiple Sclerosis Patients with Abolished Interferon-beta Bioavailability

Neutralizing antibodies (NAb) to interferon-beta (IFN-β) are associated with reduced bioactivity and efficacy of IFN-β in multiple sclerosis (MS). The myxovirus resistance protein A (MxA) gene expression is one of the most appropriate markers of biological activity of exogenous IFN-β. We hypothesize...

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Veröffentlicht in:	Medical science monitor 2015-05, Vol.21, p.1512-1519
Hauptverfasser:	Giedraitiene, Natasa, Kaubrys, Gintaras, Kizlaitiene, Rasa, Bagdonaite, Loreta, Griskevicius, Laimonas, Valceckiene, Vilma, Stoskus, Mindaugas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Neutralizing - immunology Biological Availability Biomarkers - metabolism Clinical Research Female Humans Interferon-beta - immunology Interferon-beta - pharmacokinetics Male Middle Aged Multiple Sclerosis - metabolism Multiple Sclerosis - therapy Myxovirus Resistance Proteins - metabolism Pilot Projects Plasma Exchange - methods Plasmapheresis - methods Reverse Transcriptase Polymerase Chain Reaction
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