The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1)

[Display omitted] •CYP17A1 catalyzes at least 13 different reactions with endogenous steroids.•Cytochrome b5 stimulates 17,20-lyase activity and enables andiene-β-synthase activity.•Metabolic switching occurs with deuterium labeled-progesterone substrates.•Minor products can have physiologic functio...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2015-07, Vol.151, p.52-65
Hauptverfasser:	Yoshimoto, Francis K., Auchus, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	17,20-Lyase 17-Hydroxylase Androgen Animals Catalysis Cytochrome P450 Humans Hypertension Metabolic switching Steroid 17-alpha-Hydroxylase - chemistry Steroid 17-alpha-Hydroxylase - genetics Steroid 17-alpha-Hydroxylase - metabolism Steroidogenesis Steroids - metabolism Substrate Specificity
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