PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model

The gene encoding PTPROt (truncated isoform of protein tyrosine phosphatase receptor-type O) is methylated and suppressed in chronic lymphocytc leukemia (CLL). PTPROt exhibits in vitro tumor-suppressor characteristics through the regulation of B-cell receptor (BCR) signaling. Here we generated trans...

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Veröffentlicht in:	Leukemia 2015-06, Vol.29 (6), p.1350-1359
Hauptverfasser:	Motiwala, T, Kutay, H, Zanesi, N, Frissora, F W, Mo, X, Muthusamy, N, Jacob, S T
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 38/61 631/67/1990/283/1895 631/80/86 64/110 64/60 Animals B-cell receptor B-Lymphocytes - metabolism B-Lymphocytes - pathology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blotting, Western Cancer Research CCL3 protein Cells, Cultured Chemokines Chronic lymphocytic leukemia Critical Care Medicine Development and progression Disease Models, Animal Esterases Female Flow Cytometry Forkhead Box Protein M1 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation, Leukemic Genetic aspects Hematology Humans Identification and classification Inflammation - genetics Inflammation - pathology Inflammation - prevention & control Intensive Internal Medicine Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - prevention & control Leukemogenesis Lymphocytes Lymphocytes B Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Mice, Transgenic Oligonucleotide Array Sequence Analysis Oncology original-article p53 Protein Phenotype Phenotypes Properties Protein-tyrosine-phosphatase Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcr - genetics Proto-Oncogene Proteins c-bcr - metabolism Real-Time Polymerase Chain Reaction Receptor-Like Protein Tyrosine Phosphatases, Class 3 - physiology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal Transduction Signaling Spleen Transcription activation Transgenic mice Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Tyrosine
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