Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA

CREB (cyclic AMP response element-binding protein) is a transcription factor overexpressed in normal and neoplastic myelopoiesis and regulates cell cycle progression, although its oncogenic mechanism has not been well characterized. Replication factor C3 (RFC3) is required for chromatin loading of p...

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Veröffentlicht in:	Leukemia 2015-06, Vol.29 (6), p.1379-1389
Hauptverfasser:	Chae, H-D, Mitton, B, Lacayo, N J, Sakamoto, K M
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/31 13/95 14/35 631/67 631/80/304 692/420/755 692/699/67/1990/283/1897 82/1 96/106 96/44 Acute myelocytic leukemia Acute myeloid leukemia Antigens Biotechnology Blotting, Western Cancer Research Cell cycle Cell Cycle - physiology Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Chromatin Chromatin - genetics Chromatin Immunoprecipitation Critical Care Medicine Cyclic AMP Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Deoxyribonucleic acid Development and progression DNA E2F protein Flow Cytometry Gene expression Genetic aspects Health aspects Hematology Humans Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Medicine Medicine & Public Health Metabolism Myeloid leukemia Myelopoiesis Oncology original-article Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Promoter Regions, Genetic - genetics Properties Proteins Real-Time Polymerase Chain Reaction Replication Replication Protein C - genetics Replication Protein C - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Transcription (Genetics) Transcription factors Tumor Cells, Cultured
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