A Combinatory Strategy for Detection of Live CTCs Using Microfiltration and a New Telomerase-Selective Adenovirus

Circulating tumor cells (CTC) have become an important biomarker for early cancer diagnosis, prognosis, and treatment monitoring. Recently, a replication-competent recombinant adenovirus driven by a human telomerase gene (hTERT) promoter was shown to detect live CTCs in blood samples of patients wit...

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Veröffentlicht in:	Molecular cancer therapeutics 2015-03, Vol.14 (3), p.835-843
Hauptverfasser:	Ma, Yanchun, Hao, Sijie, Wang, Shuwen, Zhao, Yuanjun, Lim, Bora, Lei, Ming, Spector, David J, El-Deiry, Wafik S, Zheng, Si-Yang, Zhu, Jiyue
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Breast Neoplasms - blood Breast Neoplasms - genetics Case-Control Studies Cell Line Cell Line, Tumor Female HCT116 Cells HEK293 Cells HT29 Cells Humans MCF-7 Cells Neoplastic Cells, Circulating - pathology Pancreatic Neoplasms - blood Pancreatic Neoplasms - genetics Promoter Regions, Genetic - genetics Telomerase - genetics
Online-Zugang:	Volltext
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