Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr

Abstract Vpr and Vpx are a group of highly related accessory proteins from primate lentiviruses. Despite the high degree of amino acid homology within this group, these proteins can be highly divergent in their functions. In this work, we constructed chimeric and mutant proteins between HIV-1 and SI...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2015-03, Vol.477, p.10-17
Hauptverfasser:	DePaula-Silva, Ana Beatriz, Cassiday, Patrick A, Chumley, Jeffrey, Bosque, Alberto, Monteiro-Filho, Carlos M.R, Mahon, Cathal S, Cone, Kelsey R, Krogan, Nevan, Elde, Nels C, Planelles, Vicente
Format:	Artikel
Sprache:	eng
Schlagworte:	Agm Cell Cycle DCAF1 DNA-Binding Proteins - metabolism Endonucleases - metabolism G2 arrest Gene Products, vpr - genetics Gene Products, vpr - metabolism HeLa Cells HIV-1 HIV-1 - physiology Host-Pathogen Interactions Humans Infectious Disease MLN4924 Monomeric GTP-Binding Proteins - metabolism Mus81 Proteolysis Recombinant Proteins - genetics Recombinant Proteins - metabolism SAM Domain and HD Domain-Containing Protein 1 SAMHD1 Simian Immunodeficiency Virus - physiology SIV Ubiquitination Vpr
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