The clinical significances of the abnormal expressions of Piwil1 and Piwil2 in colonic adenoma and adenocarcinoma
The objective of the present investigation was to study the clinical significances of the abnormal expressions of Piwil1 and Piwil2 protein in colonic adenoma and adenocarcinoma. This study had applied immunohistochemical method to detect 45 cases of tissues adjacent to carcinoma (distance to cancer...
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| Veröffentlicht in: | OncoTargets and therapy 2015-01, Vol.8, p.1259-1264 |
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| creator | Wang, Hai-Ling Chen, Bei-Bei Cao, Xin-Guang Wang, Jin Hu, Xiu-Feng Mu, Xiao-Qian Chen, Xiao-Bing |
| description | The objective of the present investigation was to study the clinical significances of the abnormal expressions of Piwil1 and Piwil2 protein in colonic adenoma and adenocarcinoma.
This study had applied immunohistochemical method to detect 45 cases of tissues adjacent to carcinoma (distance to cancerous tissue was above 5 cm), 41 cases of colonic adenoma and 92 cases of colon cancer tissues, and their Piwil1 and Piwil2 protein expression levels.
The correlation of both expression and its relationship with clinicopathological features of colon cancer was analyzed.
Positive expression rates of Piwil1 in tissues adjacent to carcinoma, colonic adenoma, and colon cancer were 11.1% (5/45), 53.7% (22/41), and 80.4% (74/92), respectively; the expression rates increased, and the comparisons between each two groups were statistically significant (P |
| doi_str_mv | 10.2147/ott.s77003 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4455855</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A447931066</galeid><sourcerecordid>A447931066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c583t-b5ed8d8de3cc4ff4b8d869ebbd1aba43fd0f73fb7dacef39aa6bf6d10c2cf9573</originalsourceid><addsrcrecordid>eNptkm1rFDEQxxdRbK2-8QPIgiAi3Jlsssnum0Ip9QEKFTxfhzxM7iLZ5JrsVf32ze3WegeSF5nM_zeTTGaq6jVGywZT_jGO4zJzjhB5Up1izLsF6wl6emCfVC9y_okQY11Dn1cnDUOMIoZOq9vVBmrtXXBa-jq7dXC2mEFDrqOtx6JKFWIaigq_twlydjFM2jf3y3lcy2Bms6ldqHX0seSqpYEQBzmpk61l0m7velk9s9JnePWwn1U_Pl2tLr8srm8-f728uF7otiPjQrVgurKAaE2tpaocWA9KGSyVpMQaZDmxihupwZJeSqYsMxjpRtu-5eSsOp_zbndqAKMhjEl6sU1ukOmPiNKJYyW4jVjHO0Fp23ZtWxKgOYGJdzBVfhT8z6vjIBrcN6yEvH-4M8XbHeRRDC5r8F4GiLssMOt43zNKuoK-ndG19CBcsLE8Qu9xcUEp7wku3SrU8j9UWQYGp2MA64r_KODdQcAGpB83OfrduO_aMfhhBnWKOSewj8VhJPZjJW5WK_F9GqsCvzn8y0f07xyRe5C8y-Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1687996438</pqid></control><display><type>article</type><title>The clinical significances of the abnormal expressions of Piwil1 and Piwil2 in colonic adenoma and adenocarcinoma</title><source>Taylor & Francis Open Access</source><source>Dove Press Free</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wang, Hai-Ling ; Chen, Bei-Bei ; Cao, Xin-Guang ; Wang, Jin ; Hu, Xiu-Feng ; Mu, Xiao-Qian ; Chen, Xiao-Bing</creator><creatorcontrib>Wang, Hai-Ling ; Chen, Bei-Bei ; Cao, Xin-Guang ; Wang, Jin ; Hu, Xiu-Feng ; Mu, Xiao-Qian ; Chen, Xiao-Bing</creatorcontrib><description>The objective of the present investigation was to study the clinical significances of the abnormal expressions of Piwil1 and Piwil2 protein in colonic adenoma and adenocarcinoma.
This study had applied immunohistochemical method to detect 45 cases of tissues adjacent to carcinoma (distance to cancerous tissue was above 5 cm), 41 cases of colonic adenoma and 92 cases of colon cancer tissues, and their Piwil1 and Piwil2 protein expression levels.
The correlation of both expression and its relationship with clinicopathological features of colon cancer was analyzed.
Positive expression rates of Piwil1 in tissues adjacent to carcinoma, colonic adenoma, and colon cancer were 11.1% (5/45), 53.7% (22/41), and 80.4% (74/92), respectively; the expression rates increased, and the comparisons between each two groups were statistically significant (P<0.05). In each group, the positive expression rates of Piwil2 were 24.4% (11/45 cases), 75.6% (31/41 cases), and 92.4% (85/92 cases); expression rates increased, and the comparisons between each two groups were statistically significant (P<0.05). Piwil1 expression and the correlation of the degree of differentiation, TNM stage, and lymph node metastasis were statistically significant (P<0.05). Piwil2 expression and the correlation of the degree of differentiation, tumor node metastasis (TNM) stage, and lymph node metastasis had no statistical significance (P>0.05). In colon cancer tissue, Piwil1 and Piwil2 expressions were positively correlated (r=0.262, P<0.05).
The results showed that the abnormal expression of Piwil1 and Piwil2 might play an important role in the process of colon cancer development.</description><identifier>ISSN: 1178-6930</identifier><identifier>EISSN: 1178-6930</identifier><identifier>DOI: 10.2147/ott.s77003</identifier><identifier>PMID: 26064060</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Adenocarcinoma ; Cellular proteins ; Colon cancer ; colonic adenoma ; Development and progression ; Gene expression ; Genetic aspects ; Health aspects ; immunohistochemical ; Original Research ; Piwil1 ; Piwil2</subject><ispartof>OncoTargets and therapy, 2015-01, Vol.8, p.1259-1264</ispartof><rights>COPYRIGHT 2015 Dove Medical Press Limited</rights><rights>2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-b5ed8d8de3cc4ff4b8d869ebbd1aba43fd0f73fb7dacef39aa6bf6d10c2cf9573</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455855/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455855/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,3862,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26064060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Hai-Ling</creatorcontrib><creatorcontrib>Chen, Bei-Bei</creatorcontrib><creatorcontrib>Cao, Xin-Guang</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Hu, Xiu-Feng</creatorcontrib><creatorcontrib>Mu, Xiao-Qian</creatorcontrib><creatorcontrib>Chen, Xiao-Bing</creatorcontrib><title>The clinical significances of the abnormal expressions of Piwil1 and Piwil2 in colonic adenoma and adenocarcinoma</title><title>OncoTargets and therapy</title><addtitle>Onco Targets Ther</addtitle><description>The objective of the present investigation was to study the clinical significances of the abnormal expressions of Piwil1 and Piwil2 protein in colonic adenoma and adenocarcinoma.
This study had applied immunohistochemical method to detect 45 cases of tissues adjacent to carcinoma (distance to cancerous tissue was above 5 cm), 41 cases of colonic adenoma and 92 cases of colon cancer tissues, and their Piwil1 and Piwil2 protein expression levels.
The correlation of both expression and its relationship with clinicopathological features of colon cancer was analyzed.
Positive expression rates of Piwil1 in tissues adjacent to carcinoma, colonic adenoma, and colon cancer were 11.1% (5/45), 53.7% (22/41), and 80.4% (74/92), respectively; the expression rates increased, and the comparisons between each two groups were statistically significant (P<0.05). In each group, the positive expression rates of Piwil2 were 24.4% (11/45 cases), 75.6% (31/41 cases), and 92.4% (85/92 cases); expression rates increased, and the comparisons between each two groups were statistically significant (P<0.05). Piwil1 expression and the correlation of the degree of differentiation, TNM stage, and lymph node metastasis were statistically significant (P<0.05). Piwil2 expression and the correlation of the degree of differentiation, tumor node metastasis (TNM) stage, and lymph node metastasis had no statistical significance (P>0.05). In colon cancer tissue, Piwil1 and Piwil2 expressions were positively correlated (r=0.262, P<0.05).
The results showed that the abnormal expression of Piwil1 and Piwil2 might play an important role in the process of colon cancer development.</description><subject>Adenocarcinoma</subject><subject>Cellular proteins</subject><subject>Colon cancer</subject><subject>colonic adenoma</subject><subject>Development and progression</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>immunohistochemical</subject><subject>Original Research</subject><subject>Piwil1</subject><subject>Piwil2</subject><issn>1178-6930</issn><issn>1178-6930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNptkm1rFDEQxxdRbK2-8QPIgiAi3Jlsssnum0Ip9QEKFTxfhzxM7iLZ5JrsVf32ze3WegeSF5nM_zeTTGaq6jVGywZT_jGO4zJzjhB5Up1izLsF6wl6emCfVC9y_okQY11Dn1cnDUOMIoZOq9vVBmrtXXBa-jq7dXC2mEFDrqOtx6JKFWIaigq_twlydjFM2jf3y3lcy2Bms6ldqHX0seSqpYEQBzmpk61l0m7velk9s9JnePWwn1U_Pl2tLr8srm8-f728uF7otiPjQrVgurKAaE2tpaocWA9KGSyVpMQaZDmxihupwZJeSqYsMxjpRtu-5eSsOp_zbndqAKMhjEl6sU1ukOmPiNKJYyW4jVjHO0Fp23ZtWxKgOYGJdzBVfhT8z6vjIBrcN6yEvH-4M8XbHeRRDC5r8F4GiLssMOt43zNKuoK-ndG19CBcsLE8Qu9xcUEp7wku3SrU8j9UWQYGp2MA64r_KODdQcAGpB83OfrduO_aMfhhBnWKOSewj8VhJPZjJW5WK_F9GqsCvzn8y0f07xyRe5C8y-Q</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Wang, Hai-Ling</creator><creator>Chen, Bei-Bei</creator><creator>Cao, Xin-Guang</creator><creator>Wang, Jin</creator><creator>Hu, Xiu-Feng</creator><creator>Mu, Xiao-Qian</creator><creator>Chen, Xiao-Bing</creator><general>Dove Medical Press Limited</general><general>Dove Press</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>The clinical significances of the abnormal expressions of Piwil1 and Piwil2 in colonic adenoma and adenocarcinoma</title><author>Wang, Hai-Ling ; Chen, Bei-Bei ; Cao, Xin-Guang ; Wang, Jin ; Hu, Xiu-Feng ; Mu, Xiao-Qian ; Chen, Xiao-Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-b5ed8d8de3cc4ff4b8d869ebbd1aba43fd0f73fb7dacef39aa6bf6d10c2cf9573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma</topic><topic>Cellular proteins</topic><topic>Colon cancer</topic><topic>colonic adenoma</topic><topic>Development and progression</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>immunohistochemical</topic><topic>Original Research</topic><topic>Piwil1</topic><topic>Piwil2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Hai-Ling</creatorcontrib><creatorcontrib>Chen, Bei-Bei</creatorcontrib><creatorcontrib>Cao, Xin-Guang</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Hu, Xiu-Feng</creatorcontrib><creatorcontrib>Mu, Xiao-Qian</creatorcontrib><creatorcontrib>Chen, Xiao-Bing</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>OncoTargets and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Hai-Ling</au><au>Chen, Bei-Bei</au><au>Cao, Xin-Guang</au><au>Wang, Jin</au><au>Hu, Xiu-Feng</au><au>Mu, Xiao-Qian</au><au>Chen, Xiao-Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical significances of the abnormal expressions of Piwil1 and Piwil2 in colonic adenoma and adenocarcinoma</atitle><jtitle>OncoTargets and therapy</jtitle><addtitle>Onco Targets Ther</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>8</volume><spage>1259</spage><epage>1264</epage><pages>1259-1264</pages><issn>1178-6930</issn><eissn>1178-6930</eissn><abstract>The objective of the present investigation was to study the clinical significances of the abnormal expressions of Piwil1 and Piwil2 protein in colonic adenoma and adenocarcinoma.
This study had applied immunohistochemical method to detect 45 cases of tissues adjacent to carcinoma (distance to cancerous tissue was above 5 cm), 41 cases of colonic adenoma and 92 cases of colon cancer tissues, and their Piwil1 and Piwil2 protein expression levels.
The correlation of both expression and its relationship with clinicopathological features of colon cancer was analyzed.
Positive expression rates of Piwil1 in tissues adjacent to carcinoma, colonic adenoma, and colon cancer were 11.1% (5/45), 53.7% (22/41), and 80.4% (74/92), respectively; the expression rates increased, and the comparisons between each two groups were statistically significant (P<0.05). In each group, the positive expression rates of Piwil2 were 24.4% (11/45 cases), 75.6% (31/41 cases), and 92.4% (85/92 cases); expression rates increased, and the comparisons between each two groups were statistically significant (P<0.05). Piwil1 expression and the correlation of the degree of differentiation, TNM stage, and lymph node metastasis were statistically significant (P<0.05). Piwil2 expression and the correlation of the degree of differentiation, tumor node metastasis (TNM) stage, and lymph node metastasis had no statistical significance (P>0.05). In colon cancer tissue, Piwil1 and Piwil2 expressions were positively correlated (r=0.262, P<0.05).
The results showed that the abnormal expression of Piwil1 and Piwil2 might play an important role in the process of colon cancer development.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>26064060</pmid><doi>10.2147/ott.s77003</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Cellular proteins Colon cancer colonic adenoma Development and progression Gene expression Genetic aspects Health aspects immunohistochemical Original Research Piwil1 Piwil2 |
| title | The clinical significances of the abnormal expressions of Piwil1 and Piwil2 in colonic adenoma and adenocarcinoma |
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