New peptide architectures through C–H activation stapling between tryptophan–phenylalanine/tyrosine residues

Natural peptides show high degrees of specificity in their biological action. However, their therapeutical profile is severely limited by their conformational freedom and metabolic instability. Stapled peptides constitute a solution to these problems and access to these structures lies on a limited...

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Veröffentlicht in:	Nature communications 2015-05, Vol.6 (1), p.7160-7160, Article 7160
Hauptverfasser:	Mendive-Tapia, Lorena, Preciado, Sara, García, Jesús, Ramón, Rosario, Kielland, Nicola, Albericio, Fernando, Lavilla, Rodolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 140/131 639/638/309 639/638/403/349 639/638/92/60 Amino Acids - chemistry Chemistry Techniques, Synthetic Humanities and Social Sciences multidisciplinary Peptides - chemical synthesis Science Science (multidisciplinary)
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