Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans

The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding proteins with versatile cytoprotective functions. In mice, disruptio...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2015-06, Vol.8 (6), p.475-486
Hauptverfasser:	Knatko, Elena V, Ibbotson, Sally H, Zhang, Ying, Higgins, Maureen, Fahey, Jed W, Talalay, Paul, Dawe, Robert S, Ferguson, James, Huang, Jeffrey T-J, Clarke, Rosemary, Zheng, Suqing, Saito, Akira, Kalra, Sukirti, Benedict, Andrea L, Honda, Tadashi, Proby, Charlotte M, Dinkova-Kostova, Albena T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Blotting, Western Female Healthy Volunteers Humans Mice Mice, Hairless Mice, Inbred C57BL Mice, Knockout Neoplasms, Radiation-Induced - etiology Neoplasms, Radiation-Induced - pathology Neoplasms, Radiation-Induced - prevention & control NF-E2-Related Factor 2 - physiology Oxidative Stress - radiation effects Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Skin - metabolism Skin - radiation effects Skin Neoplasms - etiology Skin Neoplasms - pathology Skin Neoplasms - prevention & control Solar Energy Ultraviolet Rays - adverse effects
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