Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use
ABSTRACT Aim Familial drug abuse history has been shown to have an impact on cognitive development during adolescence. The present study examined the relationship between white matter volume and cognitive processing speed in adolescents with and without a familial substance abuse history. Participa...
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| Veröffentlicht in: | Addiction (Abingdon, England) England), 2008-09, Vol.103 (9), p.1509-1520 |
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| container_title | Addiction (Abingdon, England) |
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| creator | Silveri, Marisa M Tzilos, Golfo K. Yurgelun-Todd, Deborah A. |
| description | ABSTRACT
Aim Familial drug abuse history has been shown to have an impact on cognitive development during adolescence. The present study examined the relationship between white matter volume and cognitive processing speed in adolescents with and without a familial substance abuse history.
Participants The sample comprised 33 female and male adolescents stratified by risk (family history positive, FH+) and low‐risk (FH−) groups.
Measurements Gray and white matter volumes were measured by segmenting magnetic resonance imaging (MRI) data. The neurocognitive test battery included tests that assessed processing speed, verbal ability and mental flexibility.
Findings Age‐related differences in neuropsychological functioning were seen but did not differ by risk group status, although there was some evidence for an age × gender effect. Information processing speed (digit symbol and Stroop word color naming) was correlated significantly with white matter volume; however, this pattern was observed only in FH− females. Cognitive performance and tissue volumes did not differ significantly between risk groups.
Conclusions Age‐related differences in neuropsychological functioning were seen that might, in larger samples, prove to be related to risk for substance abuse in adolescents who have not yet initiated drug use. |
| doi_str_mv | 10.1111/j.1360-0443.2008.02272.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4454456</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>57286901</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6602-6812657565bebb0915bc9991f61e491034f95cd3175cc2e69418a7136ad041003</originalsourceid><addsrcrecordid>eNqNkl9v0zAUxSMEYmPwFZCFBE-k2E7sxEggjY1tSNNAaIhHy3FuWndJXOyk7d746NyuVfnzMixLtuzfObq-PklCGJ0wHG_mE5ZJmtI8zyac0nJCOS_4ZP0gOdxfPEwOqZIi5SynB8mTGOeU0qJU-ePkgJUyk0qJw-TnV2jN4HwfZ25BKhhWAD1ZzdwApDPDAIEsfTt2QExfE-unvRvcEsgCQuNDZ3oLpB6D66fE1L6FaAGP3hJoGrBDJL4hZgqvSYT1nUNw8YagktRhnJIxwtPkUWPaCM9261Hy7ezj9clFevn5_NPJ8WVqpaQ8lSXjUhRCigqqiiomKquUYo1kkCtGs7xRwtYZK4S1HKTKWWkKbIapac4ozY6S91vfxVh1UGOZQzCtXgTXmXCrvXH675vezfTUL3WeC5wSDV7tDIL_MUIcdOfwtW1revBj1KLgpVSU3Qti5yUXlN8LMiUK_KgcwRf_gHM_hh7bhYwSqkRLhMotZIOPMUCzfxujepMaPdebcOhNOPQmNfouNXqN0ud_9ua3cBcTBF7uABOtaZuA_-7inuNUlGhaIPduy61cC7f_XYA-Pj3d7FCfbvUuDrDe60240bLICqG_X53rq2tx9uHiC6qzX2pQ7PI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199598369</pqid></control><display><type>article</type><title>Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Applied Social Sciences Index & Abstracts (ASSIA)</source><creator>Silveri, Marisa M ; Tzilos, Golfo K. ; Yurgelun-Todd, Deborah A.</creator><creatorcontrib>Silveri, Marisa M ; Tzilos, Golfo K. ; Yurgelun-Todd, Deborah A.</creatorcontrib><description>ABSTRACT
Aim Familial drug abuse history has been shown to have an impact on cognitive development during adolescence. The present study examined the relationship between white matter volume and cognitive processing speed in adolescents with and without a familial substance abuse history.
Participants The sample comprised 33 female and male adolescents stratified by risk (family history positive, FH+) and low‐risk (FH−) groups.
Measurements Gray and white matter volumes were measured by segmenting magnetic resonance imaging (MRI) data. The neurocognitive test battery included tests that assessed processing speed, verbal ability and mental flexibility.
Findings Age‐related differences in neuropsychological functioning were seen but did not differ by risk group status, although there was some evidence for an age × gender effect. Information processing speed (digit symbol and Stroop word color naming) was correlated significantly with white matter volume; however, this pattern was observed only in FH− females. Cognitive performance and tissue volumes did not differ significantly between risk groups.
Conclusions Age‐related differences in neuropsychological functioning were seen that might, in larger samples, prove to be related to risk for substance abuse in adolescents who have not yet initiated drug use.</description><identifier>ISSN: 0965-2140</identifier><identifier>EISSN: 1360-0443</identifier><identifier>DOI: 10.1111/j.1360-0443.2008.02272.x</identifier><identifier>PMID: 18636995</identifier><identifier>CODEN: ADICE5</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Addictive behaviors ; Adolescence ; Adolescent ; Adolescents ; Adult and adolescent clinical studies ; Age ; Age differences ; Age Factors ; Biological and medical sciences ; Brain ; Brain - pathology ; Brain Diseases - pathology ; Brain Diseases - physiopathology ; brain volume ; Child ; Cognition ; Cognition & reasoning ; Cognition Disorders - pathology ; Cognition Disorders - physiopathology ; cognitive development ; Cognitive performance ; Drug abuse ; Drug addiction ; Families & family life ; Family ; Family history ; Female ; Gender differences ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Neuropsychological Tests ; Neuropsychology ; Prevention and actions ; processing speed ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Factors ; sex differences ; Sex differentiation ; Sex Factors ; Social problems ; Substance abuse ; Substance-Related Disorders - pathology ; Substance-Related Disorders - physiopathology ; Teenagers</subject><ispartof>Addiction (Abingdon, England), 2008-09, Vol.103 (9), p.1509-1520</ispartof><rights>2008 The Authors. Journal compilation © 2008 Society for the Study of Addiction</rights><rights>2008 INIST-CNRS</rights><rights>Journal compilation © 2008 Society for the Study of Addiction</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6602-6812657565bebb0915bc9991f61e491034f95cd3175cc2e69418a7136ad041003</citedby><cites>FETCH-LOGICAL-c6602-6812657565bebb0915bc9991f61e491034f95cd3175cc2e69418a7136ad041003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1360-0443.2008.02272.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1360-0443.2008.02272.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,31000,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20584437$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18636995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silveri, Marisa M</creatorcontrib><creatorcontrib>Tzilos, Golfo K.</creatorcontrib><creatorcontrib>Yurgelun-Todd, Deborah A.</creatorcontrib><title>Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use</title><title>Addiction (Abingdon, England)</title><addtitle>Addiction</addtitle><description>ABSTRACT
Aim Familial drug abuse history has been shown to have an impact on cognitive development during adolescence. The present study examined the relationship between white matter volume and cognitive processing speed in adolescents with and without a familial substance abuse history.
Participants The sample comprised 33 female and male adolescents stratified by risk (family history positive, FH+) and low‐risk (FH−) groups.
Measurements Gray and white matter volumes were measured by segmenting magnetic resonance imaging (MRI) data. The neurocognitive test battery included tests that assessed processing speed, verbal ability and mental flexibility.
Findings Age‐related differences in neuropsychological functioning were seen but did not differ by risk group status, although there was some evidence for an age × gender effect. Information processing speed (digit symbol and Stroop word color naming) was correlated significantly with white matter volume; however, this pattern was observed only in FH− females. Cognitive performance and tissue volumes did not differ significantly between risk groups.
Conclusions Age‐related differences in neuropsychological functioning were seen that might, in larger samples, prove to be related to risk for substance abuse in adolescents who have not yet initiated drug use.</description><subject>Addictive behaviors</subject><subject>Adolescence</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult and adolescent clinical studies</subject><subject>Age</subject><subject>Age differences</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain Diseases - pathology</subject><subject>Brain Diseases - physiopathology</subject><subject>brain volume</subject><subject>Child</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - pathology</subject><subject>Cognition Disorders - physiopathology</subject><subject>cognitive development</subject><subject>Cognitive performance</subject><subject>Drug abuse</subject><subject>Drug addiction</subject><subject>Families & family life</subject><subject>Family</subject><subject>Family history</subject><subject>Female</subject><subject>Gender differences</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Prevention and actions</subject><subject>processing speed</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Factors</subject><subject>sex differences</subject><subject>Sex differentiation</subject><subject>Sex Factors</subject><subject>Social problems</subject><subject>Substance abuse</subject><subject>Substance-Related Disorders - pathology</subject><subject>Substance-Related Disorders - physiopathology</subject><subject>Teenagers</subject><issn>0965-2140</issn><issn>1360-0443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqNkl9v0zAUxSMEYmPwFZCFBE-k2E7sxEggjY1tSNNAaIhHy3FuWndJXOyk7d746NyuVfnzMixLtuzfObq-PklCGJ0wHG_mE5ZJmtI8zyac0nJCOS_4ZP0gOdxfPEwOqZIi5SynB8mTGOeU0qJU-ePkgJUyk0qJw-TnV2jN4HwfZ25BKhhWAD1ZzdwApDPDAIEsfTt2QExfE-unvRvcEsgCQuNDZ3oLpB6D66fE1L6FaAGP3hJoGrBDJL4hZgqvSYT1nUNw8YagktRhnJIxwtPkUWPaCM9261Hy7ezj9clFevn5_NPJ8WVqpaQ8lSXjUhRCigqqiiomKquUYo1kkCtGs7xRwtYZK4S1HKTKWWkKbIapac4ozY6S91vfxVh1UGOZQzCtXgTXmXCrvXH675vezfTUL3WeC5wSDV7tDIL_MUIcdOfwtW1revBj1KLgpVSU3Qti5yUXlN8LMiUK_KgcwRf_gHM_hh7bhYwSqkRLhMotZIOPMUCzfxujepMaPdebcOhNOPQmNfouNXqN0ud_9ua3cBcTBF7uABOtaZuA_-7inuNUlGhaIPduy61cC7f_XYA-Pj3d7FCfbvUuDrDe60240bLICqG_X53rq2tx9uHiC6qzX2pQ7PI</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Silveri, Marisa M</creator><creator>Tzilos, Golfo K.</creator><creator>Yurgelun-Todd, Deborah A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8BJ</scope><scope>FQK</scope><scope>JBE</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7QJ</scope><scope>5PM</scope></search><sort><creationdate>200809</creationdate><title>Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use</title><author>Silveri, Marisa M ; Tzilos, Golfo K. ; Yurgelun-Todd, Deborah A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6602-6812657565bebb0915bc9991f61e491034f95cd3175cc2e69418a7136ad041003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Addictive behaviors</topic><topic>Adolescence</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult and adolescent clinical studies</topic><topic>Age</topic><topic>Age differences</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brain Diseases - pathology</topic><topic>Brain Diseases - physiopathology</topic><topic>brain volume</topic><topic>Child</topic><topic>Cognition</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - pathology</topic><topic>Cognition Disorders - physiopathology</topic><topic>cognitive development</topic><topic>Cognitive performance</topic><topic>Drug abuse</topic><topic>Drug addiction</topic><topic>Families & family life</topic><topic>Family</topic><topic>Family history</topic><topic>Female</topic><topic>Gender differences</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Prevention and actions</topic><topic>processing speed</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Factors</topic><topic>sex differences</topic><topic>Sex differentiation</topic><topic>Sex Factors</topic><topic>Social problems</topic><topic>Substance abuse</topic><topic>Substance-Related Disorders - pathology</topic><topic>Substance-Related Disorders - physiopathology</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silveri, Marisa M</creatorcontrib><creatorcontrib>Tzilos, Golfo K.</creatorcontrib><creatorcontrib>Yurgelun-Todd, Deborah A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>International Bibliography of the Social Sciences (IBSS)</collection><collection>International Bibliography of the Social Sciences</collection><collection>International Bibliography of the Social Sciences</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Addiction (Abingdon, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silveri, Marisa M</au><au>Tzilos, Golfo K.</au><au>Yurgelun-Todd, Deborah A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use</atitle><jtitle>Addiction (Abingdon, England)</jtitle><addtitle>Addiction</addtitle><date>2008-09</date><risdate>2008</risdate><volume>103</volume><issue>9</issue><spage>1509</spage><epage>1520</epage><pages>1509-1520</pages><issn>0965-2140</issn><eissn>1360-0443</eissn><coden>ADICE5</coden><abstract>ABSTRACT
Aim Familial drug abuse history has been shown to have an impact on cognitive development during adolescence. The present study examined the relationship between white matter volume and cognitive processing speed in adolescents with and without a familial substance abuse history.
Participants The sample comprised 33 female and male adolescents stratified by risk (family history positive, FH+) and low‐risk (FH−) groups.
Measurements Gray and white matter volumes were measured by segmenting magnetic resonance imaging (MRI) data. The neurocognitive test battery included tests that assessed processing speed, verbal ability and mental flexibility.
Findings Age‐related differences in neuropsychological functioning were seen but did not differ by risk group status, although there was some evidence for an age × gender effect. Information processing speed (digit symbol and Stroop word color naming) was correlated significantly with white matter volume; however, this pattern was observed only in FH− females. Cognitive performance and tissue volumes did not differ significantly between risk groups.
Conclusions Age‐related differences in neuropsychological functioning were seen that might, in larger samples, prove to be related to risk for substance abuse in adolescents who have not yet initiated drug use.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18636995</pmid><doi>10.1111/j.1360-0443.2008.02272.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Addictive behaviors Adolescence Adolescent Adolescents Adult and adolescent clinical studies Age Age differences Age Factors Biological and medical sciences Brain Brain - pathology Brain Diseases - pathology Brain Diseases - physiopathology brain volume Child Cognition Cognition & reasoning Cognition Disorders - pathology Cognition Disorders - physiopathology cognitive development Cognitive performance Drug abuse Drug addiction Families & family life Family Family history Female Gender differences Humans Magnetic Resonance Imaging Male Medical sciences Neuropsychological Tests Neuropsychology Prevention and actions processing speed Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine Risk Factors sex differences Sex differentiation Sex Factors Social problems Substance abuse Substance-Related Disorders - pathology Substance-Related Disorders - physiopathology Teenagers |
| title | Relationship between white matter volume and cognitive performance during adolescence: effects of age, sex and risk for drug use |
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